PMID: 9178801May 16, 1997Paper

Patients suffering from both Hodgkin's disease and non-Hodgkin's lymphoma: a clinico-pathological and immuno-histochemical population-based study of 32 patients

International Journal of Cancer. Journal International Du Cancer
R M AminiB Glimelius

Abstract

The occurrence of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) appearing in the same individual indicates a closer relationship between the 2 diseases than previously believed. The purpose of our study was to analyze cases of HD and NHL in a defined population clinically, histopathologically and immunohistochemically to look for similarities indicating a common cellular origin. Between 1974 and 1994, 77 individuals were identified from the Swedish Cancer Registry and the National Health Care Programme for HD as potentially having both diagnoses. Thirty-two patients who had both HD and NHL were available for histo-pathological re-examination and immunohistochemical staining with CD30, CD15, LMP, p53, CD45 (LCA), CD3, CD45R0 (UCHL-1), L26, MB2 and CD45R (4KB5). The most common relation was HD preceding a high-grade malignant NHL (16 of 32 patients), unexpectedly often of T-cell phenotype (7 of 16 patients). The next common association was NHL of B-CLL type followed by HD (7 of 32 patients). At clinical presentation, the first lymphoma did not differ from lymphomas not associated with a second lymphoma, whereas the second one often appeared with a disseminated and aggressive clinical form. There was a significant correl...Continue Reading

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Citations

Dec 5, 2006·Journal of Clinical Pathology·M SteinhoffM Hummel
Feb 11, 2015·Case Reports in Oncological Medicine·Sun Hee Chang, Hye Ran Lee
Aug 3, 2002·Leukemia & Lymphoma·Rose-Marie AminiChrister Sundström
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R L Mohrmann, D A Arber
Apr 20, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·U RuefferUNKNOWN German Hodgkin's Lymphoma Study Group
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M GreenM A Zevon

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