Patients with advanced periodontal disease before intensity-modulated radiation therapy are prone to develop bone healing problems: a 2-year prospective follow-up study

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Jennifer M SchuurhuisFrederik K L Spijkervet

Abstract

Intensity-modulated radiation therapy (IMRT) has changed radiation treatment of head and neck cancer (HNC). However, it is still unclear if and how IMRT changes oral morbidity outcomes. In this prospective study, we assessed the outcome of reducing post-IMRT sequelae by means of pre-radiation dental screening and eliminating oral foci. All consecutive dentate patients > 18 years, diagnosed with primary oral or oropharyngeal carcinoma, referred for pre-treatment dental screening between May 2011 and May 2013, were included and followed for 2 years. Patients were treated with IMRT or IMRT with chemotherapy (CHIMRT). Dental screening data, demographic data, and data on oral sequelae during follow-up were recorded. Diagnosed oral foci were treated before start of the radiation therapy. Oral foci were found in 44/56 (79%) patients, consisting predominantly of periodontal breakdown. Bone healing problems after radiotherapy occurred more often in patients with periodontal pockets ≥ 6 mm at baseline (19 vs. 4% in patients with pockets < 6 mm). Osteoradionecrosis developed in 4/56 patients (7%) during follow-up. In line with this observation, multiple logistic regression analysis showed that the periodontal inflamed surface area, which ...Continue Reading

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Citations

Mar 14, 2020·Oral Diseases·Fred K L SpijkervetArjan Vissink
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Frederik K L SpijkervetArjan Vissink
Dec 21, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Laura W J BaijensPere Clavé
Dec 6, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Matthijs In 't VeldFrank K J Leusink
Mar 10, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I Brook
Jul 21, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Valeria MercadanteDouglas E Peterson
Jan 15, 2022·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Panagiotis BalermpasIlja F Ciernik

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Methods Mentioned

BETA
X-ray
PISA

Software Mentioned

CHIMRT
SPSS Statistics

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