Patients with cancer at the margins of reproductive age had reduced levels of anti-Müllerian hormone compared with patients experiencing infertility

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Mashhour NaasanEdgar Mocanu

Abstract

To compare the ovarian reserves between female patients with cancer and patients experiencing infertility. A retrospective age-matched observational study was performed at Rotunda Hospital, Dublin. The study group included data from all female oncology patients attending for oocyte or embryo cryopreservation between January 1, 2009 and December 31, 2013. Anti-Müllerian hormone (AMH) levels were recorded at patients' initial visits before beginning chemotherapy or radiotherapy. The control group included patients without cancer who had their AMH levels recorded to investigate fertility or as a baseline level prior to beginning assisted reproductive treatment. The records of 118 oncology and 5231 control patients from the study period were identified. There was no difference in AMH levels between patients in the oncology and control groups aged 30-38years; however, significantly lower AMH levels were observed in patients in the oncology group aged 29years and younger (17.89pmol/L vs 23.35pmol/L; P=0.015), or at least 39years (2.65pmol/L vs 5.87pmol/L; P=0.028). Before commencing chemotherapy or radiotherapy, patients in the oncology group at the margins of reproductive age had a diminished ovarian reserve compared with the contro...Continue Reading

References

Jun 16, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J G SchenkerE Schenker
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S VivianiG Bonadonna
Jan 1, 1997·Human Reproduction·A BotchanH Yavetz
Aug 26, 1998·The Journal of Endocrinology·A H Lane, P K Donahoe
Mar 25, 2000·Fertility and Sterility·C L CookM E Fallat
Aug 15, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology· FitoussiB Hoerni
Nov 8, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U RuefferV Diehl
Feb 1, 2002·Fertility and Sterility·Annemarie de VetBart C J M Fauser
Mar 24, 2005·Journal of the National Cancer Institute. Monographs·Axel P N Themmen
Sep 14, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Luciano G NardoIan Laing
Nov 18, 2008·Fertility and Sterility·Rudolpho B QuinteroLynn M Westphal
Jun 2, 2011·Annals of Clinical Biochemistry·A M WallaceS M Nelson
Apr 5, 2012·The Journal of Clinical Endocrinology and Metabolism·Mark F H BroughamW Hamish B Wallace

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved