Patients with cardiorenal syndrome revealed increased neurohormonal activity, tubular and myocardial damage compared to heart failure patients with preserved renal function

Cardiorenal Medicine
Alberto PalazzuoliRanuccio Nuti

Abstract

Cardiorenal syndrome (CRS) is associated with increased cardiovascular morbidity and mortality; still, its biomarker pattern has been poorly evaluated so far. The aim of this study was to measure the inflammatory activation, neurohormonal status and kidney and myocardial damage in patients with CRS compared to patients with heart failure (HF) without renal impairment (RI). We analyzed 246 patients on the basis of renal function (group 1: 120 HF patients without RI; group 2: 126 CRS patients). In each group, interleukin-6, tumor necrosis factor-α, B-type natriuretic peptide (BNP), neutrophil gelatinase-associated lipocalin (NGAL), troponin T (TnT), osteoprotegerin and blood urea nitrogen (BUN) were measured. The diagnostic power of all laboratory parameters to detect CRS was evaluated by the receiver operating characteristic (ROC) curve and logistic regression analysis. A significant increase in BNP [626.4 pg/ml, confidence interval (CI) 518-749 vs. 487.8 pg/ml, CI 411-578; p < 0.05], NGAL (156 ng/ml, CI 129-186 vs. 89.1 ng/ml, CI 72-109; p < 0.0001), BUN (108.9 mg/dl, CI 98-120 vs. 51 mg/dl, CI 46-55; p < 0,0001) and TnT (0.62 ng/ml, CI 0.51-0.75 vs. 0.21 ng/ml, CI 0.15-0.28; p < 0.001) was seen in CRS patients compared to HF p...Continue Reading

Citations

Aug 3, 2017·Circulation. Heart Failure·Lekha K GeorgeCsaba P Kovesdy
Mar 12, 2019·Circulation·Janani RangaswamiUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
Mar 12, 2019·Expert Review of Proteomics·Eleni PetraAntonia Vlahou
Feb 14, 2020·Nature Reviews. Nephrology·Matthew T JamesMarcello Tonelli
Aug 17, 2018·Experimental and Therapeutic Medicine·Xiaosheng ShengMingxing Ding
Jul 7, 2021·Korean Circulation Journal·Sung Yoon Lim, Sejoong Kim

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