Patients with community-acquired bacteremia of unknown origin: clinical characteristics and usefulness of microbiological results for therapeutic issues: a single-center cohort study

Annals of Clinical Microbiology and Antimicrobials
Johan CourjonPierre-Marie Roger

Abstract

Bacteremia of unknown origin (BUO) are associated with increased mortality compared to those with identified sources. Microbiological data of those patients could help to characterize an appropriate empirical antibiotic treatment before bloodcultures results are available during sepsis of unknown origin. Based on the dashboard of our ward that prospectively records several parameters from each hospitalization, we report 101 community-acquired BUO selected among 1989 bacteremic patients from July 2005 to April 2016, BUO being defined by the absence of clinical and paraclinical infectious focus and no other microbiological samples retrieving the bacteria isolated from blood cultures. The in-hospital mortality rate was 9%. We retrospectively tested two antibiotic associations: amoxicillin-clavulanic acid + gentamicin (AMC/GM) and 3rd generation cephalosporin + gentamicin (3GC/GM) considered as active if the causative bacteria was susceptible to at least one of the two drugs. The mean age was 71 years with 67% of male, 31 (31%) were immunocompromised and 52 (51%) had severe sepsis. Eleven patients had polymicrobial infections. The leading bacterial species involved were Escherichia coli 25/115 (22%), group D Streptococci 12/115 (10...Continue Reading

References

Feb 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L LeiboviciM Drucker
Apr 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M P WeinsteinL B Reller
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·B RenaudUNKNOWN ICU-Bacteremia Study Group
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine ChirouzeBruno Hoen
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G PedersenH T Sørensen
Jun 2, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M OrtegaJ Mensa
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R CantónT M Coque
Nov 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M PaulJ Bishara
Jan 17, 2014·The Journal of Infection·Fredrikke Christie KnudtzenCourt Pedersen
Jun 9, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C HernandezJ A Martinez
Oct 4, 2014·Clinical Microbiology Reviews·Karsten BeckerGeorg Peters
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Kristel MarquetNeree Claes
Aug 27, 2015·Critical Care : the Official Journal of the Critical Care Forum·José Garnacho-MonteroJosé María López-Sánchez
Feb 19, 2016·Virulence·Claudio Viscoli
Nov 7, 2016·Critical Care : the Official Journal of the Critical Care Forum·Damien ContouNicolas de Prost

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Citations

Feb 2, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Johan CourjonPierre-Marie Roger
Nov 23, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Charlotte AilletPierre-Marie Roger
Nov 7, 2017·Journal of Applied Toxicology : JAT·Xiao KuangHongzhuo Liu
Jun 3, 2021·International Journal of Environmental Research and Public Health·Won Soek YangWon Young Kim
Jun 23, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Rehab El-SokkaryJordi Rello

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Methods Mentioned

BETA
biopsies

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