Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile

EBioMedicine
Frank VrielingSimone A Joosten

Abstract

Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlying molecular foundations are unclear. Since lipids play a central role in the development of both DM and TB, lipid metabolism may be important for TB-DM pathophysiology. A 1H NMR spectroscopy-based platform was used to determine 225 lipid and other metabolic intermediates in plasma samples of healthy controls (n = 50) and patients with TB (n = 50), DM (n = 50) or TB-DM (n = 27). TB patients presented with wasting disease, represented by decreased amino acid levels including histidine and alanine. Conversely, DM patients were dyslipidemic as evidenced by high levels of very low-density lipoprotein triglycerides and low high-density lipoprotein cholesterol. TB-DM patients displayed metabolic characteristics of both wasting and dyslipidemia combined with disease interaction-specific increases in phospholipid metabolites (e.g. sphingomyelins) and atherogenic remnant-like lipoprotein particles. Biomarker analysis identified the ratios of phenylalanine/histidine and esterified cholesterol/sphingomyelin as markers for TB classification regardless of DM-status. TB-DM patients possess a distinctive plasma lipid profile with pro...Continue Reading

Citations

Mar 10, 2020·Pathogens and Disease·Elinor Hortle, Stefan H Oehlers
Jan 11, 2020·Frontiers in Immunology·Milla R McLeanAmy W Chung
Oct 23, 2019·Frontiers in Cellular and Infection Microbiology·Cristian Alfredo Segura-CerdaMario Alberto Flores-Valdez
Aug 11, 2021·The European Respiratory Journal·Rupak ShivakotiChandrasekaran Padmapriyadarsini

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Methods Mentioned

BETA
acetylation
metabolomic profiling
NMR

Software Mentioned

phenotypicForest
R
TANDEM
Graphpad Prism
MetaboAnalyst
limma
mixOmics
DA
SPSS
PLS

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