PMID: 9187415Apr 1, 1997Paper

Patients with diabetes mellitus and atherosclerosis; a role for cytomegalovirus?

Diabetes Research and Clinical Practice
F L VisserenR J Diepersloot

Abstract

Diabetic patients are known to have an impaired immune response to viral antigens and a high incidence of atherosclerosis. This study was initiated to evaluate the association between cytomegalovirus infection and atherosclerosis in patients with diabetes mellitus. Patients with diabetes mellitus type 1 and 2 (> 5 years) with (group A) and without (group B) clinical signs of atherosclerosis were included. Cytomegalovirus cultures were obtained, serum was screened for CMV-antibodies and CMV-IgG and CMV-IgM titers were determined. Cytomegalovirus antibodies were detected more often in diabetic patients with atherosclerosis compared to patients without atherosclerosis (70.7 vs. 45.2%, P = 0.018. In female patients the prevalence of CMV-antibodies was 89.5 vs. 40.0% (P = 0.0037). CMV IgG titers were twice as high in group A compared to group B. Cytomegalovirus was cultured from four urine samples and two throat swabs in group B and in one urine and one throat swab in group A. The prevalence of cytomegalovirus antibodies was higher in diabetic patients with atherosclerosis compared to diabetic patients without atherosclerosis. This difference was most striking in the female population. CMV-IgG titers were twice as high in the athero...Continue Reading

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Citations

Oct 21, 2000·Journal of Clinical Pathology·S A MorréH W Niessen
Oct 31, 2002·European Journal of Clinical Investigation·J J M BouwmanR J A Diepersloot
Jun 27, 2006·European Journal of Clinical Investigation·M C A BlansK P Bouter
Dec 14, 1999·The Journal of Laboratory and Clinical Medicine·F L VisserenD W Erkelens
Aug 20, 2005·Southern Medical Journal·Bertram W Roberts, Irina Cech
Jan 23, 1999·Current Opinion in Rheumatology·T JuvonenM J Savolainen
May 18, 2017·Journal of Medical Virology·Yang-Jie JiaLi-Hong Liu

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