Patients with Diabetes Mellitus are Prone to Develop Severe Hepatitis and Liver Failure due to Hepatitis Virus Infection

Journal of Clinical and Experimental Hepatology
Kumar K SinghSubrat K Acharya

Abstract

Acute viral hepatitis (AVH) is usually a self-limiting illness. Diabetics are prone to develop liver diseases and liver regeneration is impaired in them. Natural course of AVH in diabetics has not been assessed and may be severe. Observational prospective study to evaluate natural course of AVH in patients with and without diabetes mellitus. Consecutive patients with AVH were included and categorized in to those with or without diabetes. Etiology, complications, mortality and recovery parameters of AVH were identified and compared between two groups. 131 consecutive AVH between March 2007 and March 2009 were evaluated; 12 diabetics and 83 non-diabetics (n = 95) were included for analysis. Hepatitis E was the commonest cause (n = 55, 57.89%) in the whole cohort. However, Hepatitis B virus (HBV) as the etiology was significantly higher among diabetics than in non-diabetics (58.33% vs. 25.3%, P = 0.02). In contrast, hepatitis E was the etiology in 61.44% of non-diabetics. Frequency of severe hepatitis was significantly higher in diabetics than in non-diabetics (5/12; 41.67% vs. 9/83; 10.64%, P < 0.005). 5 of 14 (36%) with severe hepatitis were diabetics. Liver failure and death occurred in 2 (16%) diabetics, while none among the n...Continue Reading

Citations

Jun 10, 2016·Nature Reviews. Disease Primers·Vicente ArroyoBernd Schnabl
Jan 7, 2017·World Journal of Gastroenterology : WJG·Chong ChenLiang Chen
Nov 17, 2016·Clinical Journal of Gastroenterology·Yoshifumi MiuraOsamu Yokosuka
Oct 18, 2016·Current Gastroenterology Reports·Shiv Kumar Sarin, Ashok Choudhury
Sep 6, 2020·International Journal of Molecular Sciences·Tatsuo KandaMitsuhiko Moriyama
May 18, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Aaron KoenigZobair M Younossi
May 17, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Mirko FaberKlaus Stark
Aug 2, 2016·Clinics and Practice·Mohammed HasosahAbdullah Alzaben
Apr 28, 2021·European Journal of Gastroenterology & Hepatology·Ahmed El RayMahmoud Sherbiny

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