Patients with diabetic retinopathy have high retinal venous pressure

The EPMA Journal
Anna K Cybulska-HeinrichJ Flammer

Abstract

The introduction of ophthalmodynamometric measurement of retinal venous pressure (RVP) now permits the quantification, or at least an approximation, of the real pressure in the retinal veins. We measured the RVP of healthy control subjects, patients with diabetes without diabetic retinopathy (nonDR) and patients with diabetes and diabetic retinopathy (DR). The mean ± SD RVP for the control, nonDR and DR groups were 23.4 ± 7.33, 22.5 ± 5.78 and 37.7 ± 10.1 mmHg, respectively. In the diabetes patients with DR, the RVP was markedly and significantly increased, and this result was significantly age dependent. RVP was not increased in the group of diabetes patients without DR. In our tested population, diabetes had a minor influence on intraocular pressure. Regardless of the cause, a marked increase in RVP in diabetes patients with DR is clinically relevant, as it reduces perfusion pressure and increases transmural pressure. The reduced perfusion pressure contributes to hypoxia, and the increased transmural pressure can facilitate retinal edema. Diabetes is an increasing burden, and DR is one of its most severe complications. Strategies to recognize the risk for DR and to develop personalized prevention and therapy therefore have ma...Continue Reading

References

Oct 10, 1994·Archives of Internal Medicine·R KleinK J Cruickshanks
Jul 26, 2003·The British Journal of Ophthalmology·J B Jonas
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Nathan G CongdonThomas Lietman
Dec 16, 2004·Klinische Monatsblätter für Augenheilkunde·R Meyer-SchwickerathK Hartmann
Oct 13, 2006·The British Journal of Ophthalmology·Chandrakumar BalaratnasingamDao-Yi Yu
Nov 15, 2006·American Journal of Ophthalmology·Jost B Jonas, Bjoern Harder
May 26, 2007·American Journal of Ophthalmology·Annette KifleyPaul Mitchell
Jul 22, 2008·Klinische Monatsblätter für Augenheilkunde·R Stodtmeister
Oct 23, 2009·The British Journal of Ophthalmology·Sam KainDao-Yi Yu
Jan 12, 2010·Retina·Zvia Burgansky-EliashAdiel Barak
May 28, 2010·Investigative Ophthalmology & Visual Science·Richard StodtmeisterAndreas G Boehm
Dec 9, 2010·European Heart Journal·Gerald LiewJie Jin Wang
Feb 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Adviye Ergul
Sep 1, 2011·Retina·Zvia Burgansky-EliashArdon Rubinstein
Apr 21, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Roxanne Crosby-NwaobiSobha Sivaprasad
Feb 13, 2013·European Heart Journal·Josef FlammerStefano Taddei
May 30, 2013·Investigative Ophthalmology & Visual Science·Richard StodtmeisterLutz E Pillunat
Jun 8, 2013·The EPMA Journal·Josef FlammerAndreas J Flammer

❮ Previous
Next ❯

Citations

Oct 28, 2015·The EPMA Journal·Josef Flammer, Katarzyna Konieczka
Jul 21, 2017·The EPMA Journal·Tilo BlechschmidtMargarita G Todorova
Oct 30, 2018·Investigative Ophthalmology & Visual Science·Yen-Lin ChenTravis W Hein
Feb 19, 2016·Clinical Hemorheology and Microcirculation·Thomas NeumannChristian Jung
Jul 21, 2017·The EPMA Journal·Josef Flammer, Katarzyna Konieczka
Jan 13, 2021·Klinische Monatsblätter für Augenheilkunde·Richard StodtmeisterLutz E Pillunat
Jan 16, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Teruyo KidaTsunehiko Ikeda
Jan 17, 2019·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Galina Dimitrova, Etsuo Chihara

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.