Patients with Diffuse Axonal Injury Can Recover to a Favorable Long-Term Functional and Quality of Life Outcome

Journal of Neurotrauma
Marleen van EijckGerwin Roks

Abstract

Functional outcome and quality of life are difficult to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI). The primary aim of this cross-sectional cohort study was to assess the long-term functional outcome in patients with DAI and to identify prognostic factors. Second, health-related quality of life (HRQL) at long-term follow-up was assessed. Patients ≥16 years of age with TBI and DAI (admitted 2008-2014) were included. Clinical and imaging data were collected. The primary outcome parameter was the Glasgow Outcome Scale Extended (GOSE) at long-term follow-up. Second, the HRQL was assessed with the Quality Of Life after Brain Injury (QOLIBRI) questionnaire. DAI was diagnosed in 185 patients. Long-term functional outcome was obtained in 134 patients (72%), median follow-up was 54 months (range 14-100); and 51% had a favorable outcome (GOSE 6-8). Independent prognostic factors were age, pupillary reaction, Hb, DAI grading, and return of consciousness ≤7 days. Sixty-two percent had a good HRQL, after a median follow-up of 57 months (range 14-100) with age as an independent prognostic factor. More than half of patients with DAI had a favorable functional outcome and a good HRQL at long-term fo...Continue Reading

References

Jan 1, 1995·Acta Neuropathologica·S M GentlemanD I Graham
Apr 1, 1994·Radiology·L R Gentry
Sep 24, 2005·Journal of Neurosurgery·Matilde IngleseRobert I Grossman
Feb 14, 2008·BMJ : British Medical Journal·UNKNOWN MRC CRASH Trial CollaboratorsSurakrant Yutthakasemsunt
Feb 19, 2009·Acta neurochirurgica·Alfonso LagaresRamiro D Lobato
Mar 26, 2009·Journal of Neurotrauma·Cody A ChastainKaren A Tong
Mar 10, 2010·Journal of Neurotrauma·Nicole von SteinbüchelUNKNOWN QOLIBRI Task Force
Jan 13, 2011·Statistics in Medicine·Ian R WhiteAngela M Wood
May 19, 2011·Critical Care : the Official Journal of the Critical Care Forum·Bob RoozenbeekUNKNOWN CRASH (Corticosteroid Randomisation After Significant Head Injury) Trial Collaborators
Jul 26, 2011·Journal of Neurosurgery·Hidetoshi MatsukawaRyoichi Ishikawa
Oct 12, 2011·Current Opinion in Neurology·David J Sharp, Timothy E Ham
Aug 31, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Kent Gøran MoenAnne Vik
Nov 8, 2012·Journal of Korean Neurosurgical Society·Sang Won ChungSung Nam Hwang
Apr 20, 2014·Journal of Neurotrauma·Esther L YuhGeoffrey T Manley
Jun 15, 2016·Journal of Neurotrauma·Lindsay WilsonJean-Luc Truelle

❮ Previous
Next ❯

Citations

Oct 2, 2019·Current Opinion in Critical Care·Jeroen T J M van DijckUNKNOWN all focus group participants
Jun 6, 2020·Health and Quality of Life Outcomes·Katrin RauenNikolaus Plesnila
Dec 5, 2021·Journal of Neurotrauma·David A ZuckermanYelena G Bodien

❮ Previous
Next ❯

Methods Mentioned

BETA
ISS

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.