Patients with inflammatory bowel disease have higher abdominal adiposity and less skeletal mass than healthy controls

Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology
Teresa BarrosoKonstantinos Gerasimidis

Abstract

Abdominal fat type and distribution have been associated with complicated Crohn's disease and adverse postoperative outcomes. Few studies have assessed the abdominal distribution of fat and lean stores in patients with inflammatory bowel disease (IBD) and compared this with healthy controls. This retrospective study aimed to compare the abdominal body composition in IBD patients who failed medical treatment and who underwent computed tomography (CT) imaging prior to gastrointestinal surgery with healthy controls. Associations between preoperative abdominal body composition and postoperative outcomes within a year of surgery were explored. Abdominal body composition was evaluated in 22 presurgical patients with medically refractory IBD (18 with Crohn's disease) and 22 healthy controls, using routinely acquired CT. Total fat, subcutaneous fat, visceral fat, and skeletal muscle cross-sectional area were measured. An independent disease effect was observed, explaining a fat deposition excess of 38 cm2 and a skeletal muscle deficit of 15 cm2 in IBD. Abdominal skeletal muscle correlated with visceral fat for the control (rho=0.51, P=0.015), but not for the IBD group (rho=-0.13, P=0.553). A positive correlation observed between subcut...Continue Reading

Citations

Sep 25, 2019·Journal of Crohn's & Colitis·Michel AdaminaMiranda Lomer
May 1, 2021·International Journal of Molecular Sciences·Eva KaraskovaDavid Karasek

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