Patients with polycystic ovary syndrome have lower levels of IgM anti-phosphorylcholine antibodies than healthy women

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Malin GingnellInger Sundstrom-Poromaa

Abstract

IgM antibodies against phosphorylcholine (IgM anti-PC) are natural autoantibodies, possibly exerting one of the atheroprotective functions of the immune system. Increased levels of these antibodies reduce the development of atherosclerosis in mice, and low levels of IgM anti-PC have been associated with increased risk for cardiovascular disease (CVD). This study compared levels of IgM anti-PC in women with polycystic ovary syndrome (PCOS, n = 111) and healthy controls (n = 79). Levels of IgM anti-PC were measured with ELISA. The median level of IgM anti-PC in patients with PCOS was not significantly different compared to control subjects. However, the proportion of patients with PCOS with low levels of IgM anti-PC, defined as number of individuals below the median level, was significantly higher than among healthy controls, p < 0.05. Patients with PCOS in the oldest age quintile had significantly lower level of IgM anti-PC than control subjects of similar age (p < 0.05) and younger women with PCOS (p < 0.01). Our results indicate that women with PCOS more frequently display below-median levels of IgM anti-PC than controls and older women with PCOS have lower median anti-PC levels. Further studies of how this finding translates ...Continue Reading

References

Jul 23, 1998·Journal of Clinical Epidemiology·T PierpointH S Jacobs
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Dec 8, 2004·The Journal of Experimental Medicine·Mi-Kyung ChangJoseph L Witztum
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
May 18, 2005·Journal of Lipid Research·Christoph J BinderJoseph L Witztum
Nov 30, 2005·Atherosclerosis·Andrea J CussonsGerald F Watts
May 10, 2006·Journal of the American College of Cardiology·Pamela OuyangRichard H Karas
Feb 21, 2007·Circulation·Lori MoscaUNKNOWN American College of Nurse Practitioners
Aug 7, 2007·Journal of the American College of Cardiology·Giuseppina CaligiuriAntonino Nicoletti
Mar 7, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Asa LindholmInger Sundström-Poromaa
Sep 19, 2008·Journal of Cardiovascular Medicine·Francesco GiallauriaCarlo Vigorito
Jan 23, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kai I CheangWalter Futterweit
Apr 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Hans GrönlundJohan Frostegård
Sep 18, 2009·Annals of the New York Academy of Sciences·Ulf de Faire, Johan Frostegård

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Citations

Dec 14, 2011·Autoimmunity Reviews·Jana Petríková, Ivica Lazúrová
Dec 9, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana PetrikovaJan Rosocha
Jan 8, 2017·Journal of Cellular Physiology·Salimeh EbrahimnezhadAmir Avan
Dec 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew ElvingtonStephen Tomlinson

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