Patients with problematic opioid use can be weaned from codeine without pain escalation

Acta Anaesthesiologica Scandinavica
H K NilsenP C Borchgrevink

Abstract

Brief treatments for chronic non-malignant pain patients with problematic opioid use are warranted. The aims of the present study were to investigate (1) whether it is possible to withdraw codeine use in such patients with a brief cognitive-behavioural therapy (CBT), (2) whether this could be done without pain escalation and reduction in quality of life and (3) to explore the effects of codeine reduction on neurocognitive functioning. Eleven patients using codeine daily corresponding to 40-100 mg morphine were included. Two specifically trained physicians treated the patients with six CBT sessions, tapering codeine gradually within 8 weeks. Codeine use, pain intensity, quality of life and neuropsychological functioning were assessed at pre-treatment to the 3-month follow-up. Codeine use was significantly reduced from mean 237 mg [standard deviation (SD) 65] pre-treatment to 45 mg (SD 66) post-treatment and to 48 mg (SD 65) at follow-up without significant pain escalation or reductions in quality of life. Moreover, neuropsychological functioning improved significantly on some tests, while others remained unchanged. The promising findings of codeine reduction in this weaning therapy programme for pain patients with problematic op...Continue Reading

References

Jun 1, 1992·The Clinical Journal of Pain·D A FishbainR S Rosomoff
Jan 1, 1984·Journal of Clinical Pharmacology·H QuidingA M Sjöblad
Feb 1, 1997·Archives of General Psychiatry·J M GoldD R Weinberger
Aug 10, 1999·Journal of Pain and Symptom Management·S M FishmanD Borsook
Oct 16, 1999·Acta Anaesthesiologica Scandinavica·S R Savage
Sep 13, 2000·Neuropsychology Review·R P HartN D Zasler
Dec 22, 2000·Spine·J E Ware
Dec 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M OldervollJ H Loge
Jan 28, 2003·Journal of Pain and Symptom Management·Pål KlepstadStein Kaasa
Aug 26, 2003·European Journal of Pain : EJP·Eija KalsoMichael Zenz
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Shawn R CurrieSusan Armstrong
Dec 9, 2003·Pain·Jørgen EriksenNiels K Rasmussen
Jun 11, 2004·Clinical Therapeutics·Steven D PassikJeffrey R Schein
Aug 24, 2004·The Clinical Journal of Pain·San KellerCharles S Cleeland
Mar 2, 2005·European Journal of Pain : EJP·Harald Breivik
Aug 13, 2005·European Journal of Pain : EJP·Harald BreivikDerek Gallacher
Oct 31, 2006·European Journal of Pain : EJP·Jette Højsted, Per Sjøgren
May 8, 2007·Pain·Jane C Ballantyne, Steven K LaForge
Nov 17, 2007·Acta Anaesthesiologica Scandinavica·O M S FredheimP C Borchgrevink
Dec 29, 2007·European Journal of Pain : EJP·Katri HamunenEija Kalso

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Citations

Nov 6, 2018·Pain Management·Joseph V PergolizziJohn Bisney
Nov 27, 2018·Clinical Obstetrics and Gynecology·Austin D Findley, Emily Kemner
Feb 27, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Natalia BienekChristine H Meyer-Frießem
Apr 16, 2013·American Journal of Therapeutics·Daniel W BerlandRobert Przybylski
Mar 14, 2020·JMIR Research Protocols·Jacqui McCoyRaimondo Bruno
Jan 1, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·David A Fishbain, Aditya Pulikal
Aug 14, 2019·Pain Practice : the Official Journal of World Institute of Pain·Aaron C OckerEugene R Viscusi
May 28, 2019·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Ronen ShechterMarie N Hanna
Apr 19, 2018·Physical Therapy·Sarah WengerJoke Bradt
Sep 22, 2017·Current Pain and Headache Reports·Shweta Teckchandani, Meredith Barad
Jun 1, 2018·The Medical Journal of Australia·Suzanne NielsenJacinta L Johnson
Apr 27, 2021·Seminars in Nephrology·Carrie E BrintzUNKNOWN HOPE Consortium
Apr 30, 2021·Early Intervention in Psychiatry·Jean Nicolas WestenbergReinhard M Krausz
Feb 18, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marcelina Jasmine SilvaMarc O Martel
Apr 28, 2011·Current Opinion in Supportive and Palliative Care

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