Patients with severe obstructive sleep apnea syndrome and elevated high-sensitivity C-reactive protein need priority treatment

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Li-Ang LeeHsueh-Yu Li

Abstract

To evaluate the clinical factors predicting the significantly elevated high-sensitivity C-reactive protein (hs-CRP) concentrations, defined herein as hs-CRP > or = 3 mg/L, in adult males with untreated obstructive sleep apnea syndrome (OSAS). Cross-sectional study. Tertiary referral center. Sixty-five consecutive male patients with newly diagnosed OSAS were enrolled to receive complete medical history review, physical examination, in-laboratory overnight polysomnography, and hs-CRP test. The patients had no current or history of cardiovascular disease. The patients had a mean age of 38.2 +/- 9.9 years, body mass index (BMI) of 27.4 +/- 3.5 kg/m(2), and Epworth Sleepiness Scale (ESS) of 11.3 +/- 4.6. The serum levels of hs-CRP were assessed using peripheral venous blood samples. Twenty-three percent of the overall patients had significantly elevated serum levels of hs-CRP. The increase of hs-CRP correlated fairly with BMI, apnea-hypopnea index (AHI), tonsil size, and ESS (r = 0.450, 0.398, 0.393, and 0.300, respectively; all P < or = 0.05) after adjustment for conventional coronary heart disease risk factors. However, only the AHI could predict for significantly elevated hs-CRP after stepwise multiple linear regression (R(2) = 0...Continue Reading

References

May 30, 2002·Circulation·Abu S M ShamsuzzamanVirend K Somers
Aug 2, 2002·Current Opinion in Cardiology·Robert S Rosenson, Wolfgang Koenig
Dec 17, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ning-Hung ChenPa-Chun Wang
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Umesh N KhotEric J Topol
Apr 20, 2004·The Laryngoscope·Michael FriedmanNinos J Joseph
May 4, 2004·European Heart Journal·Olivier MilleronOlivier Dubourg
Jul 6, 2004·The American Journal of Medicine·Antonia BarcelóAlvar G N Agustí
Feb 3, 2005·Sleep·Christian GuilleminaultMaurice M Ohayon
Mar 30, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·O RogowskiD Zeltser
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Lorenzi-Filho
Feb 16, 2006·Chest·Murat CanSelda Demirtas
Dec 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael FriedmanNinos J Joseph
Jan 2, 2007·The European Respiratory Journal·W T McNicholasUNKNOWN Management Committee of EU COST ACTION B26
Oct 2, 2008·The European Respiratory Journal·P LévyC Ribuot
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Olle MelanderThomas J Wang

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Citations

Oct 12, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mao-Chang SuHsin-Ching Lin
Jan 13, 2016·Sleep & Breathing = Schlaf & Atmung·Woo Hyun Lee, Jeong-Whun Kim
Oct 16, 2016·Medicine·Yu-Shu HuangLi-Ang Lee
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Li-Ang LeeHsueh-Yu Li
Aug 30, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Arzu TatlipinarTanju Gökçeer
May 21, 2015·World Journal of Experimental Medicine·Izolde BouloukakiSophia E Schiza
Mar 27, 2020·International Journal of Molecular Sciences·David Sanz-RubioJose M Marin

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