Patients with Spinal Cord Injuries Favor Administration of Methylprednisolone

PloS One
Christian A BowersGregory W J Hawryluk

Abstract

Methylprednisolone sodium succinate (MPSS) for treatment of acute spinal cord injury (SCI) has been associated with both benefits and adverse events. MPSS administration was the standard of care for acute SCI until recently when its use has become controversial. Patients with SCI have had little input in the debate, thus we sought to learn their opinions regarding administration of MPSS. A summary of the published literature to date on MPSS use for acute SCI was created and adjudicated by 28 SCI experts. This summary was then emailed to 384 chronic SCI patients along with a survey that interrogated the patients' neurological deficits, communication with physicians and their views on MPSS administration. 77 out of 384 patients completed the survey. 28 respondents indicated being able to speak early after injury and of these 24 reported arriving at the hospital within 8 hours of injury. One recalled a physician speaking to them about MPSS and one patient reported choosing whether or not to receive MPSS. 59.4% felt that the small neurological benefits associated with MPSS were 'very important' to them (p<0.0001). Patients had 'little concern' for potential side-effects of MPSS (p = 0.001). Only 1.4% felt that MPSS should not be gi...Continue Reading

References

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Citations

Nov 26, 2016·Neurosurgery Clinics of North America·Michael Karsy, Gregory Hawryluk
May 8, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jayne Donovan, Steven Kirshblum
Apr 1, 2021·The International Journal of Neuroscience·Jaspreet Kaur, Aditya Mojumdar

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Software Mentioned

MPSS
Excel
BRIEFLY
REDCap
R Statistical Software

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