Patients with stage II of the knee osteoarthritis most likely benefit from the intra-articular injections of autologous adipose tissue-from 2 years of follow-up studies.

Archives of Orthopaedic and Trauma Surgery
Paweł BąkowskiTomasz Piontek

Abstract

Knee osteoarthritis (OA) is a common, chronic, progressive and degenerative disease which affects patients' quality of life and may cause disability and social isolation. OA is a huge economic burden for the patient and a large strain for the whole healthcare system. Articular cartilage has a small potential to repair, with progressively more clinicians emphasizing cellular therapy. Subcutaneous fat tissue in human body is a large reservoir of mesenchymal stem cells (MSCs) and is been harvested in minimally invasive, simple procedure. The purpose of this study was to define a specific group of patients with knee osteoarthritis, who are the most likely to benefit from the treatment with intra-articular injection of an autologous adipose tissue (AAT). From 2016 to 2018, 59 symptomatic bilateral and unilateral knee OA patients were treated with a single intra-articular (IA) injection of an autologous adipose tissue (AAT). Before the treatment and at the follow-up, the participant was asked to fulfill the Knee Injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee 2000 (IKDC 2000), The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Health Questionnaire EQ-5D-5L an...Continue Reading

References

Apr 21, 2004·Annals of Biomedical Engineering·Thomas P AndriacchiSeungbum Koo
Nov 8, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Francis Berenbaum, Jérémie Sellam
Jul 6, 2011·Cell Stem Cell·Arnold I Caplan, Diego Correa
Sep 13, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomasz PiontekMichał Słomczykowski
Nov 12, 2013·Primary Care·Rafaelani L Taruc-Uy, Scott A Lynch
Nov 14, 2015·Journal of Cellular Physiology·Arnold I Caplan
Feb 26, 2016·Annals of Physical and Rehabilitation Medicine·Clémence PalazzoSerge Poiraudeau
Mar 24, 2016·The Cochrane Database of Systematic Reviews·Else Marie BartelsHans Lund
Apr 30, 2017·Stem Cells Translational Medicine·Arnold I Caplan
Oct 29, 2017·Archives of Orthopaedic and Trauma Surgery·Sabine Patricia SingerMichael C Liebensteiner
Apr 10, 2018·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Jorge Chahla, Bert R Mandelbaum
Mar 28, 2019·Stem Cells International·Sara NavaGiulio Alessandri
Jan 23, 2020·Current Reviews in Musculoskeletal Medicine·Armin ArshiKristofer J Jones

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