Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes

Diabetes, Obesity & Metabolism
C J GirmanL Katz

Abstract

The aetiology of acute pancreatitis (AP) is complex, and many risk factors for AP are shared by patients with type 2 diabetes mellitus (T2DM). However, few have assessed risk factors for AP specifically in T2DM patients. Patients in the General Practice Research Database (2 984 755, 5.0% with T2DM) were used to estimate incidence of AP for T2DM relative to non-diabetes, adjusting for prior pancreatitis, gallbladder disease, obesity, smoking and alcohol use. Multivariate Cox regression analysis adjusting for risk factors and Charlson comorbidity index (CCI) was used to estimate hazard ratios (HR) with 95% confidence intervals (CI). Between 2003 and 2007, 301 of 148 903 patients with T2DM and 2434 of almost 3 million patients without diabetes developed AP. Patients with T2DM had higher risk for AP compared with patients without diabetes (crude HR: 2.89, 95% CI: 2.56-3.27). Patients with T2DM had significantly higher rates of prior alcohol and tobacco exposure (44.2 and 61.9% vs. 34.1 and 35.9%, p < 0.001) and of comorbid conditions (14.7% with CCI > or =1 vs. 4.3%, p < 0.001). Histories of obesity, pancreatitis, gallbladder disease, smoking or alcohol use were significant predictors of AP. After adjusting for these factors, age, ...Continue Reading

References

Apr 1, 1996·Scandinavian Journal of Gastroenterology·F A Halvorsen, S Ritland
Apr 23, 1999·Lancet·T Walley, A Mantgani
Dec 1, 2000·Scandinavian Journal of Gastroenterology·I A ElandB H Stricker
Aug 6, 2005·Journal of Clinical Gastroenterology·Chirag D Trivedi, C S Pitchumoni
May 19, 2006·The New England Journal of Medicine·David C Whitcomb
Oct 13, 2006·The American Journal of Gastroenterology·Peter A BanksUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Nov 15, 2006·Scandinavian Journal of Gastroenterology·Ingo A ElandUNKNOWN EDIP Study Group of the European Pharmacovigilance Research Group
Mar 31, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nison BadalovScott Tenner
Apr 24, 2007·Annals of Epidemiology·Peter J FagenholzCarlos A Camargo
May 9, 2007·Gastroenterology·Chris E ForsmarkUNKNOWN AGA Institute Governing Board
Aug 31, 2007·Drugs of Today·Rohtashav DhirKevin W Olden
Jan 22, 2008·Best Practice & Research. Clinical Gastroenterology·B W M SpanierM J Bruno
Mar 19, 2009·The American Journal of Gastroenterology·Wayne TsuangAndres Gelrud
May 27, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Paul Georg LankischAlbert B Lowenfels
Jan 7, 2010·BMC Family Practice·Nada F KhanPeter W Rose

❮ Previous
Next ❯

Citations

Aug 1, 2012·Diabetes Technology & Therapeutics·John A RomleyAnne L Peters
Jul 16, 2013·Pancreas·Tomas Sjöberg BexeliusJesper Lagergren
Jun 14, 2012·Endocrine-related Cancer·Roman VangoitsenhovenBart Van der Schueren
Apr 26, 2014·BMJ : British Medical Journal·Jean-Luc FaillieSamy Suissa
May 27, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hsin-Chun ChouFei-Yuan Hsiao
Dec 20, 2013·Acta Diabetologica·Jean-Luc FaillieUNKNOWN French Pharmacovigilance Centers Network
Jan 23, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Chris E Forsmark
Nov 22, 2014·Postgraduate Medicine·Louis KuritzkyLaura Fernández Landó
Aug 8, 2013·Expert Opinion on Pharmacotherapy·Carolyn F Deacon, Jens J Holst
Oct 2, 2014·Expert Opinion on Drug Safety·Jocelyn de Heer, Burkhard Göke
Apr 30, 2013·Expert Opinion on Drug Safety·Andre Scheen
Sep 3, 2014·Current Medical Research and Opinion·Elizabeth A SuarezSybil Abraham
Oct 9, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Viktor OskarssonAlicja Wolk
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Nicholas S SolankiGino T P Saccone
Aug 18, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Björn LindkvistJonas Manjer
Apr 30, 2013·Gastroenterology·Dhiraj Yadav, Albert B Lowenfels
Dec 3, 2014·The American Journal of Pathology·Teresa Vanessa FiorentinoFranco Folli
Apr 29, 2015·Case Reports in Medicine·Aura Diana ReghinaSimona Fica
Sep 16, 2015·Postgraduate Medicine·Charles F ShaeferRichard Aguilar
Apr 18, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·H-N ShenC-Y Li
Mar 16, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·M WentenG L Bloomgren
Oct 15, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·R E J RyderUNKNOWN ABCD nationwide exenatide and liraglutide audit contributors
Mar 26, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·T M E DavisW A Davis
Jan 14, 2011·The American Journal of Medicine·Bernard Zinman
Jan 27, 2015·Lancet·Paul Georg LankischPeter A Banks
Nov 18, 2014·International Journal of Experimental Pathology·Dietmar ZechnerBrigitte Vollmar
Jan 15, 2015·The Journal of Small Animal Practice·L J Davison
Jan 31, 2015·Diabetes Care·Reimar Wernich ThomsenHenrik Toft Sørensen
Jul 4, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Bernard E Tuch
May 6, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Haq NawazDhiraj Yadav
Apr 22, 2014·Molecular Metabolism·Alessandro Pocai

❮ Previous
Next ❯

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