Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele

Autoimmunity
Dorette Raaz-SchrauderMartin Herrmann

Abstract

Patients with Systemic Lupus Erythematosus (SLE) carry an increased risk for the development of coronary artery disease (CAD). The R131 allele of the Fc gamma receptor IIa (FcγRIIa) is associated with SLE incidence and disease severity but also with CAD. Compared to stable angina pectoris (SAP) the unstable angina (UAP), as a manifestation of destabilizing CAD, is associated with increased risk of persistent instability, myocardial infarction, and death. Identification of clinically relevant determinants for unstable angina promises reduction of UAP-associated mortality in patients with SLE. We conducted a clinical study among 553 consecutive patients with stable angina pectoris (n = 330) and unstable angina pectoris (n = 223). All patients were genotyped for a frequent functional variant at position 131 of the mature FcγRIIa. UAP, but not SAP was significantly associated with the R/R131 genotype (P < 0.001). In troponin-negative patients with angina carrying the R/R131 genotype the odds ratio for suffering from UAP was 4.02 (95% confidence interval, 2.52-6.41) compared to those with non-R/R131 genotypes. In a multivariable analysis, the R/R131 genotype independently predicted the risk for development of UAP in a model adjusted...Continue Reading

References

Mar 1, 1992·Arthritis and Rheumatism·D DeapenT M Mack
Apr 5, 1997·Annals of the New York Academy of Sciences·A RascuJ G van de Winkel
Mar 3, 1999·JAMA : the Journal of the American Medical Association·S SavonittoE J Topol
Aug 17, 1999·The Journal of Experimental Medicine·D BharadwajT W Du Clos
Jul 6, 2000·Circulation·C W Hamm, E Braunwald
Jul 5, 2002·The New England Journal of Medicine·Antonino BuffonAttilio Maseri
Apr 16, 2003·Tissue Antigens·N M van SorgeJ G J van de Winkel
Aug 16, 2003·Science·Hedda WardemannMichel C Nussenzweig
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
May 25, 2005·Atherosclerosis·Sonia GavassoChristian A Vedeler
Jun 17, 2005·The New England Journal of Medicine·Jonathan Abrams
Oct 21, 2006·Circulation Research·Purificación Hernández-VargasCarmen Gómez-Guerrero
Feb 29, 2008·The New England Journal of Medicine·Anisur Rahman, David A Isenberg
Jun 27, 2008·Current Opinion in Immunology·Angelo A ManfrediAlberto Mantovani
May 30, 2009·Arthritis and Rheumatism·Luis E MuñozUdo S Gaipl
Mar 2, 2010·Autoimmunity·Luis E MunozMartin Herrmann
Oct 27, 2010·Genetic Testing and Molecular Biomarkers·Christos KroupisAthanassios Manginas
Apr 7, 2011·Nature Reviews. Rheumatology·Benjamin RhodesTimothy J Vyse
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Kim Ohl, Klaus Tenbrock

❮ Previous
Next ❯

Citations

Aug 27, 2013·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Sep 23, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Thijs W H FlinsenbergMarianne Boes
Oct 23, 2015·Inflammation·Jaqueline BepplerFabiano Pinheiro da Silva
May 4, 2015·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Nicholas G Kounis
Jan 17, 2015·Circulation Research·Keiji TanigakiPhilip W Shaul
Apr 4, 2019·Frontiers in Immunology·Jessica C AnaniaP Mark Hogarth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.