Pattern and predictors of immunologic recovery in HIV infected patients

BMC Research Notes
Theophilus B KwofieA Dompreh

Abstract

Although anti-retroviral therapy has generally improved the survival of HIV infected patients in many developing countries including Ghana, specific socio-demographic factors could still influence outcome of treatment. This study was designed to identify patient-specific factors that could influence the immune recovery of absolute CD4 count in HIV infected patients. Hospital records were extracted from two health facilities in Ghana. The impact of socio-demographic factors type of ART and baseline category of CD4 counts were assessed at six monthly interval using robust linear mixed models. A total of 214 follow up records were reviewed at Komfo Anokye Teaching Hospital (KATH) and the Kumasi South Hospital (KSH). One hundred (46.7%) were from KATH and 114 (53.3%) were from KSH. There was a general increase in the level of CD4 counts with time, however this increase significantly slowed down with subsequent reviews (p < 0.001). On the average the rate of CD4 count recovery slowed down by 43.6 cells/µl for every 6 months of follow up (SE = 7.69; p < 0.001). Similarly the recovery of CD4 counts in subjects with an initial high baseline CD4 counts decreased by 192.6 cells/µl (SD error = 42.3, p value ≤0.001). All other variables we...Continue Reading

References

Mar 10, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A L MooreM Johnson
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Aug 19, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Moses R KamyaUNKNOWN Academic Alliance for AIDS Care and Prevention in Africa
May 2, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sam EggerUNKNOWN Asia Pacific HIV Observational Database (APHOD)
Sep 17, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C TortiI Frank
Jun 9, 2012·BMC Infectious Diseases·Christian ObirikorangIsaac Acheampong
Aug 19, 2014·Journal of the International AIDS Society·Agnes N KiraggaUNKNOWN East Africa IeDEA Regional Consortium

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