Pattern classification of volitional functional magnetic resonance imaging responses in patients with severe brain injury.

Archives of Neurology
Jonathan C BardinHenning U Voss

Abstract

Recent neuroimaging investigations have explored the use of mental imagery tasks as proxies for an overt motor response, in which patients are asked to imagine performing a task, such as "Imagine yourself swimming." To detect covert volitional brain activity in patients with severe brain injury using pattern classification of the blood oxygenation level-dependent (BOLD) response during mental imagery and to compare these results with those of a univariate functional magnetic resonance imaging analysis. Case-control study. Academic research. Experiments were performed in 8 healthy control subjects and in 5 patients with severe brain injury. The patients with severe brain injury constituted a convenience sample. Functional magnetic resonance imaging data were acquired as the patients were asked to follow commands or to answer questions using motor imagery as a proxy response. In the controls, the responses were accurately classified. In the patient group, the responses of 3 of 5 patients were correctly classified. The remaining 2 patients showed no significant BOLD response in a standard univariate analysis, suggesting that they did not perform the task. In addition, we showed that a classifier trained on command-following data c...Continue Reading

Citations

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