Pattern Generation and Information Transfer through a Liquid/Liquid Interface in 3D Constitutional Dynamic Networks of Imine Ligands in Response to Metal Cation Effectors

Journal of the American Chemical Society
Artem OsypenkoJean-Marie Lehn

Abstract

The immense discriminative capacity of the human olfactory chemosensory systems relies on the generation of a combinatorial signal in response to the interaction of a particular odorant molecule with many different olfactory receptors. In this work, we report the generation of distributional signals by the action of particular effectors, here metal cations, on dynamic covalent libraries (DCLs) of receptor molecules, here ligands for metal cations. Different effectors are discriminated by the formation of different constitutional distributions, which result from the adaptation of the DCL to the action of a particular cation effector through the selection and exchange of components. Compartmentalization by operation in a system of immiscible solvents (here water and chloroform) results in a 3D constitutional dynamic network (CDN), effecting distributional signal and information transfer between two domains, through the interface from the "writing" input phase (the IN-phase) and the "reading" output phase (the OUT-phase). Here, it is not the selectivity of a specific recognition process between a particular DCL member and a given effector that is key to the information processing, but the change in the distribution of the componen...Continue Reading

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Citations

Apr 4, 2020·Angewandte Chemie·Marion KiefferJonathan R Nitschke
Jan 12, 2020·Nature Communications·Ignacio ColomerStephen P Fletcher
Sep 26, 2020·Chemical Communications : Chem Comm·Jordi SolàIgnacio Alfonso
Oct 29, 2020·Chemistry, an Asian Journal·Cheng LiuHuaping Xu
Aug 14, 2020·Journal of the American Chemical Society·Stefania GambaroPlacido Neri
Nov 13, 2019·Journal of the American Chemical Society·Meixia He, Jean-Marie Lehn
Jul 15, 2020·Organic Letters·Thamon Puangsamlee, Ognjen Š Miljanić
Mar 17, 2020·Journal of the American Chemical Society·Jean-François AymeLydia Karmazin
Dec 24, 2020·Journal of the American Chemical Society·Zhixin ZhouItamar Willner

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