Pattern of 24-hour ambulatory blood pressure monitoring in type 2 diabetic patients with cardiovascular dysautonomy

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Claudia R L CardosoGil F Salles

Abstract

The pathophysiological mechanisms linking cardiovascular dysautonomy to mortality are unclear. The aim of this study was to investigate the pattern of 24-h ambulatory blood pressure (BP) monitoring (ABPM) in diabetic patients with cardiovascular autonomic neuropathy (CAN). We evaluated 391 type 2 diabetic patients in a cross-sectional study. Five clinical tests of CAN were performed: heart-rate variation during deep breathing, the Valsalva maneuver, and standing, and BP variation during handgrip and standing. Patients were considered to have initial CAN if one heart-rate test was abnormal or two were borderline, and to have definite or severe CAN if at least two tests were abnormal. Differences between patients with and without CAN were assessed by bivariate tests and ANCOVA. Of the 391 patients, 230 (59%) presented clinical CAN, of whom 53 had definite or severe involvement. Patients with CAN were older, had diabetes of longer duration, and had an equal prevalence of hypertension but used more antihypertensive drugs than those without CAN. On ABPM, patients with definite or severe CAN had higher systolic BP (SBP) and pulse pressures (PP) than those without CAN, particularly in the nighttime (SBP: 128 +/- 18 vs. 117 +/- 16 mmHg...Continue Reading

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Citations

Aug 26, 2014·Diabetes Research and Clinical Practice·Claudia Rl CardosoGil F Salles
Jun 8, 2013·Acta Diabetologica·Claudia R L CardosoGil F Salles
Sep 15, 2012·La Presse médicale·Marie-Christine VantyghemAnne-Sophie Balavoine
Feb 24, 2012·Diabetes Care·Steven OrlovBruce A Perkins
May 24, 2016·Journal of Diabetes and Its Complications·Denise S CostaClaudia R L Cardoso
Oct 1, 2011·American Journal of Hypertension·Claudia R L CardosoGil F Salles
May 13, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Claudia Rl CardosoGil F Salles
Jun 11, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gil F SallesClaudia R L Cardoso
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Rajiv Vij, Aldo J Peixoto
Jul 29, 2009·Chronobiology International·Jose Cabezas-CerratoDiana Elva Ayala
Apr 13, 2012·Journal of Hypertension·Claudia R L CardosoGil F Salles
Dec 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Wen SuMing C Gong
Jun 4, 2020·Arquivos brasileiros de cardiologia·Fernando Antonio de Almeida
Jan 26, 2021·Frontiers in Endocrinology·Chin-Hsiao TsengJau-Jiuan Sheu

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