Pattern of adverse drug reactions to anti-epileptic drugs: a cross-sectional one-year survey at a tertiary care hospital

Pharmacoepidemiology and Drug Safety
Roopa B SChanda Kulkarni

Abstract

To investigate pattern and extent of adverse drug reactions (ADRs) associated with AEDs and to identify safer options for treatment of epilepsy. Study was a retrospective, cross-sectional survey. Data from patients with epilepsy at the out-patient and in-patient of Neurology Department was collected in a specially designed proforma. Causality and severity of ADRs was categorized as per WHO guidelines. Among 788 patients with epilepsy, 80 (10.27%) had ADRs. ADRs with AED monotherapy were 9.18% and with polytherapy were 11.56%. ADRs with conventional and newer AED monotherapy was 10.24% and 6.84%, respectively, and were maximum with phenytoin and clobazam (14.28% and 12.5%). ADRs were mild in 4.16%, moderate in 70.83% and severe in 25% patients. Causality was probable in 65.62%, possible in 13.54% and definite in 20.83%. Patients (15/80) were hospitalized due to ADRs. Age and gender distribution showed statistically significant difference in occurrence of ADRs (p < 0.05). Chi-square test for poly versus monotherapy and conventional versus newer AEDs did not show any significant difference. Study showed maximum ADRs with AED polytherapy with no significant difference in frequency and severity of ADRs between conventional versus ne...Continue Reading

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Citations

Jul 19, 2013·Clinical Neuropharmacology·Dipika BansalVishal Guglani
Nov 20, 2013·BMC Research Notes·Mansur HabibQuazi Deen Mohammad
Dec 17, 2008·Pharmacoepidemiology and Drug Safety
May 4, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Cristian Gonzalez-GonzalezAdolfo Figueiras
Mar 5, 2020·Advanced Healthcare Materials·Seungmin LeeHongsoo Choi
Mar 18, 2011·Clinical Neuropharmacology·Soha NamaziIman Karimzadeh

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