Pattern of cortical reorganization in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study

Experimental Brain Research
C KonradB R Brooks

Abstract

Depending on individual lesion location and extent, reorganization of the human motor system has been observed with a high interindividual variability. In addition, variability of forces exerted, of motor effort, and of movement strategies complicates the interpretation of functional imaging studies. We hypothesize that a general pattern of reorganization can be identified if a homogeneous patient population is chosen and experimental conditions are controlled. Patients with amyotrophic lateral sclerosis (ALS) and healthy volunteers were trained to perform a simple finger flexion task with 10% of each individual's maximum grip force with constant movement amplitude and frequency. The activation pattern in ALS patients was distinctly different to that in healthy controls: In ALS patients, motor cortex activation was located more anteriorly, encompassing the premotor gyrus. The cluster volume within the supplementary motor area (SMA) was higher and shifted toward the pre-SMA. Contralateral inferior area 6 and bilateral parietal area 40 revealed higher cluster volumes. Our results demonstrate a general pattern of functional changes after motor neuron degeneration. They support the concept of a structurally parallel and functionall...Continue Reading

Citations

Feb 8, 2006·Experimental Brain Research·C KonradS Knecht
Mar 19, 2013·Experimental Brain Research·F FioriG Bottini
Mar 8, 2005·Journal of Neurology·Mircea Ariel SchoenfeldS Vielhaber
Nov 12, 2005·Journal of Neurology·C KonradS Knecht
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sumei WangJohn H Woo
Oct 1, 2013·Cognitive Neuroscience·Mili S KuruvillaDaniel L Murman
Nov 15, 2011·Brain : a Journal of Neurology·Gwenaëlle DouaudMartin R Turner
Feb 9, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FilippiUNKNOWN European Federation of Neurological Societies
Aug 1, 2012·Neurology Research International·Katja KolleweBahram Mohammadi
Nov 9, 2012·BMC Neuroscience·Carsten KeilJulian Grosskreutz
Aug 1, 2013·Journal of Neural Transmission·R SankaranarayaniT R Raju
Jun 27, 2012·Biomarkers in Medicine·Martin R TurnerEsther Verstraete
Jun 21, 2014·BioMed Research International·Pierre-François Pradat, Mohamed-Mounir El Mendili
Jan 25, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Nataša BizovičarJanez Zidar
Apr 3, 2010·AJNR. American Journal of Neuroradiology·F AgostaM Filippi
Jan 27, 2016·Journal of the Neurological Sciences·Ari ShemeshMarc Gotkine
Feb 14, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·N RivaL Leocani
May 18, 2010·Revue neurologique·P-F PradatUNKNOWN coordination des centres de prise en charge des patients atteints de SLA
Apr 24, 2009·La Presse médicale·Pierre-François Pradat
Mar 25, 2008·Neuroscience Letters·Yutaka FuchinoTakeshi Yoro
Feb 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masashi HamadaYoshikazu Ugawa
Jan 13, 2009·Acta Neurologica Scandinavica·B KoritnikJ Zidar
Mar 31, 2012·Human Brain Mapping·Aurélia PoujoisJean-Christophe Antoine
Apr 13, 2011·Human Brain Mapping·Bahram MohammadiThomas F Münte
Sep 4, 2007·Brain Research·Biba R StantonAndrew Simmons
Mar 31, 2006·Journal of the Neurological Sciences·Kristin H ScheuerIan Law
Mar 10, 2006·Journal of the Neurological Sciences·Carsten Konrad
May 2, 2006·Brain Research Bulletin·A TessitoreG Tedeschi
Jan 23, 2015·NeuroImage. Clinical·Avner MeodedMary Kay Floeter
Jul 23, 2014·Muscle & Nerve·Alexander V ChervyakovMichael A Piradov
Apr 10, 2013·Neuroscience Letters·Stefanie Blain-MoraesUncheol Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.