Pattern of drinking and feeding produced by hypothalamic norepinephrine injection in the satiated rat.

Physiology & Behavior
S F Leibowitz

Abstract

Injection of norepinephrine into the perifornical region of the anterior hypothalamus elicited both drinking and feeding in satiated rats. Analysis of these behaviors revealed the following: (1) Both responses were dose-dependent, occurring at doses at least as low as 0.5 mug. (2) The drinking response (1-4 ml) had a latency of around 1.5 min and a duration of 2-3 min. It was followed within a minute or two by eating (2-4 g) that lasted approximately 20 min. It was also followed by a period of drinking suppression that lasted approximately 60 min. (3) Satiation from the ingestion process appeared to be a primary factor in terminating the elicited feeding response, whereas a time-related factor was important in terminating the elicited drinking. (4) These ingestive responses produced by noradrenergic stimulation of the anterior perifornical hypothalamus were found to bear striking similarities to the rat's natural feeding behavior and premeal component of his natural food-associated drinking behavior. (5) These noradrenergically elicited responses could not be observed with lateral hypothalamic stimulation, while only feeding was elicited by ventromedial hypothalamic stimulation. (6) The drinking induced by central noradrenergic...Continue Reading

References

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Citations

Dec 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·S M TolpygoK V Sudakov
Jul 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·O S GorbatiukI G Akmaev
Oct 15, 1981·European Journal of Pharmacology·P SchmidtJ Nagy
Aug 1, 1985·Physiology & Behavior·G Shor-PosnerS F Leibowitz
Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·J van der Gugten, J L Slangen
Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·N Rowland, D J Engle
Feb 1, 1978·Pharmacology, Biochemistry, and Behavior·S F Leibowitz
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·N Munaro, E Chiaraviglio
Jan 1, 1986·Pharmacology, Biochemistry, and Behavior·D M DenbowP B Siegel
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·G Shor-PosnerS F Leibowitz
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·A TowellP Willner
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·M BerlanP Montastruc
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·J C CalleraW A Saad
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·A MorienJ Fojt
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·D M Denbow
Jan 1, 1984·Pharmacology & Therapeutics·L M Fuller
Jan 1, 1985·Psychoneuroendocrinology·C R RolandS F Leibowitz
Sep 1, 1977·Brain Research Bulletin·J R Ieni, R M Gold
Oct 1, 1984·Brain Research Bulletin·S S LichtensteinS F Leibowitz
Nov 1, 1986·Brain Research Bulletin·G Shor-PosnerS F Leibowitz
Nov 1, 1986·Brain Research Bulletin·S F LeibowitzJ A Grinker
Jan 2, 1997·Brain Research. Developmental Brain Research·S ChoiC K Kellogg
Nov 5, 1998·Regulatory Peptides·G HollopeterR D Palmiter

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