Pattern of expression of cyclin D1/CDK4 complex in human placenta during gestation

Cell and Tissue Research
Maria De FalcoA De Luca

Abstract

Progression through the cell cycle in eukaryotic cells is controlled by a family of protein kinases, termed cyclin-dependent kinases (CDKs), and their specific partners, the cyclins. In particular, the control of mammalian cell proliferation occurs largely during the G1 phase of the cell cycle. Five mammalian G1 cyclins have been enumerated to date: cyclins D1, D2, and D3 (D-type cyclins), and cyclins E and E2. By the use of immunohistochemistry and immunoelectron microscopy, we observed that in the first trimester of gestation of human placenta, cyclin D1 was distributed in the nuclei of the cytotrophoblast compartment together with a weak positivity of endothelial cells surrounding blood vessels. The endothelial positivity of cyclin D1 strongly increased in the third trimester of gestation. Moreover, we observed the subcellular localization of cyclin D1 that was present both in the stroma of placental villi and in the nuclei of syncytiotrophoblast cells. Therefore, we observed that CDK4 was localized in the nuclei of the cytotrophoblast compartment during the first and third trimesters and it also had a nuclear positivity in the endothelial cells of blood vessels at the end of the third trimester of gestation. In conclusion w...Continue Reading

Citations

Jul 27, 2011·Histochemistry and Cell Biology·Emin Turkay KorgunGernot Desoye
Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jianguo Hu, Rui Yuan
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jianguo Hu, Rui Yuan
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Biao ZengKai Kang
Dec 29, 2012·The International Journal of Biochemistry & Cell Biology·Haifeng ZhangLiwei Wang
Jun 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tang YiweiLong Xiang
Dec 4, 2004·Journal of Anatomy·Maria De FalcoAntonio De Luca
Aug 12, 2008·Journal of Anatomy·Luigi CobellisAntonio De Luca
Apr 8, 2014·American Journal of Reproductive Immunology : AJRI·Quaker E HarmonAndrew F Olshan
Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Chen WangHai-Chang Wang
Feb 23, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xian XiaMing Yue
Nov 7, 2021·European Journal of Clinical Nutrition·P KochharA Mukhopadhyay

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