Pattern-of-failure and salvage treatment analysis after chemoradiotherapy for inoperable stage III non-small cell lung cancer.

Radiation Oncology
Julian TaugnerFarkhad Manapov

Abstract

Loco-regional and distant failure are common in inoperable stage III non small-cell lung cancer (NSCLC) after chemoradiotherapy (CRT). However, there is limited real-world data on failure pattern, patient prognosis and salvage options. We analysed 99 consecutive patients with inoperable stage III NSCLC treated with CRT between 2011 and 2016. Follow up CT scans from date of the first-site failure were matched with the delivered radiation treatment plans. Intra-thoracic loco-regional relapse was defined as in-field (IFR) vs. out-of-field recurrence (OFR) [in- vs. outside 50Gy isodose line in the involved lung], respectively. Extracranial distant (DMs) and brain metastases (BMs) as first site of recurrence were also evaluated. Using the Kaplan-Meier method, impact of salvage surgery (sS), radiotherapy (sRT), chemotherapy (sCT) and immunotherapy (sIO) on patient survival was assessed. Median follow-up was 60.0 months. Median PFS from the end of CRT for the entire cohort was 7.5 (95% CI: 6.0-9.0 months) months. Twenty-six (26%) and 25 (25%) patients developed IFR and OFR. Median time to diagnosis of IFR and OFR was 7.2 and 6.2 months. In the entire cohort, onset of IFR and OFR did not influence patient outcome. However, in 73 (74%) ...Continue Reading

References

Dec 3, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N AndroulakisV Georgoulias
Jun 20, 2003·The New England Journal of Medicine·Didier LardinoisHans C Steinert
Sep 1, 2004·The Annals of Thoracic Surgery·Robert James CerfolioAlfred A Bartolucci
Nov 24, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Angelika Zabel, Jürgen Debus
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Michael P Mac ManusDavid L Ball
Apr 4, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Everett E VokesUNKNOWN Cancer and Leukemia Group B
Feb 20, 2008·Clinical Lung Cancer·Gigi ChenDerick Lau
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
May 26, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C SoriaT Le Chevalier
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Noelle O'RourkeFergus Macbeth
Sep 11, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah A McAvoyDaniel R Gomez
Feb 19, 2016·OncoTargets and Therapy·Wang JingHui Zhu
Mar 15, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C DickhoffK J Hartemink
Apr 6, 2017·Clinical Lung Cancer·Oscar Juan, Sanjay Popat
Aug 22, 2017·Seminars in Thoracic and Cardiovascular Surgery·Monica CasiraghiLorenzo Spaggiari
Sep 5, 2017·Practical Radiation Oncology·Jennifer C HoJoe Y Chang
Sep 9, 2017·The New England Journal of Medicine·Scott J AntoniaUNKNOWN PACIFIC Investigators
Sep 25, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vivek VermaCharles B Simone
Dec 6, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Emmanuel JouglarLine Claude
Jun 8, 2018·Translational Lung Cancer Research·Zhongxing Liao, Charles B Simone
Jun 8, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Olarn RoengvoraphojFarkhad Manapov
Sep 13, 2018·Journal of Thoracic Disease·Melissa A L VyfhuisCharles B Simone
Sep 13, 2018·Journal of Thoracic Disease·Vasu Tumati, Puneeth Iyengar
Oct 4, 2018·The New England Journal of Medicine·Scott J AntoniaUNKNOWN PACIFIC Investigators
Jan 8, 2019·The Korean Journal of Internal Medicine·Sung Won Lim, Myung-Ju Ahn
Apr 3, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ingmar SchlamppStefan Rieken
Jun 5, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jacek RutkowskiJacek Jassem
Jun 16, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Laura Romero-VielvaRafael Rosell
Aug 27, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Nicholas BodorMartin J Edelman

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
H L ManningJ C Leiter
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Miguel Nobre MenezesPedro Canas da Silva
© 2022 Meta ULC. All rights reserved