Pattern of follicular growth and steroidogenesis in the ovary of aging cycling rats

Experimental Aging Research
J J PelusoJ Meites

Abstract

Prior to the cessation of reproductive cycles, older female rats exhibit irregular and prolonged cycles due to alterations in the hypothalamic-pituitary-ovarian axis. In order to evaluate the age-related changes in the ovary, the histology, and estradiol, testosterone and progesterone concentrations within the ovaries of mature regular cycling (4--5 mo. old) and older irregular cycling (10--11 mo. old) rats were examined. At estrus, the number of non-atretic growing follicles (150--300u in diameter) was greater in the mature than in the older rats (18 +/- 1.5 vs 4.5 +/- 1.4). However, the number of preovulatory follicles on proestrus did not differ (6.0 +/- 1.2 vs 5.5 +/- 0.6). Estradiol, testosterone and progesterone concentrations on proestrus in mature rats averaged 38.8 pg, 56.1 pg, and 1.0 ng/ml of ovary, respectively. In the older proestrous rat, only estradiol was altered, increasing to 124.3 pg/mg. In addition, many of the preovulatory follicles within the aged ovary were larger (greater than 600u in diameter) than those within the mature ovary. On the day of estrus virtually all preovulatory follicles ovulated in the mature rat, whereas large follicles, less than or equal to 600u in diameter, remained in the older ovar...Continue Reading

References

Sep 1, 1976·Journal of Reproduction and Fertility·R W StegerJ Meites
Mar 1, 1977·Journal of Reproduction and Fertility·J J PelusoE S Hafez
Jul 1, 1977·Endocrinology·C S CampbellM G Firlit
Jul 1, 1977·Journal of Gerontology·S W Chan, J H Leathem
Dec 1, 1977·Endocrinology·G A EvansM G Rosenfeld
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Jul 1, 1977·The Anatomical Record·S L Quattropani
Mar 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J H Leathem, B H Shapiro
Jan 1, 1975·Neuroendocrinology·H Huang, J Meites
Sep 15, 1974·Experientia·M OyaM Asano
Oct 1, 1968·American Journal of Obstetrics and Gynecology·G B Talbert
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Citations

Jan 1, 1982·Cell and Tissue Research·J J Peluso, C Downey
May 15, 1990·Mechanisms of Ageing and Development·F FerranteF Amenta
Feb 1, 1992·Mechanisms of Ageing and Development·H ZhanJ H Zhou
Jan 1, 1982·Experimental Aging Research·R W Steger, J J Peluso
Feb 17, 2010·Reproductive Biology and Endocrinology : RB&E·Irina Y LebedevaNahid Parvizi
Aug 1, 1987·Environmental Health Perspectives·C A Montgomery, R H Alison
May 31, 2013·Reproductive Biology·Kazutoshi NishijimaShuji Kitajima
Sep 28, 2014·Brain Research·Stephanie L BakerCatherine Bielajew
Nov 2, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Gonzalo CruzAlfonso H Paredes
Jan 9, 2018·Journal of the Endocrine Society·Katrina M VolkNatalia Toporikova
Aug 28, 2020·Frontiers in Neurology·Andrew N StewartMelinda E Wilson
Jul 1, 1987·Veterinary Pathology·L S KellerC M Lang

Related Concepts

Senility
Estradiol, (16 alpha,17 beta)-Isomer
Estrus
Atretic Follicle
Ovarian Cysts
Ovary
Ovulation
Progesterone, (9 beta,10 alpha)-Isomer
Sterotate

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