Pattern of follicular growth and steroidogenesis in the ovary of aging cycling rats

Experimental Aging Research
J J PelusoJ Meites


Prior to the cessation of reproductive cycles, older female rats exhibit irregular and prolonged cycles due to alterations in the hypothalamic-pituitary-ovarian axis. In order to evaluate the age-related changes in the ovary, the histology, and estradiol, testosterone and progesterone concentrations within the ovaries of mature regular cycling (4--5 mo. old) and older irregular cycling (10--11 mo. old) rats were examined. At estrus, the number of non-atretic growing follicles (150--300u in diameter) was greater in the mature than in the older rats (18 +/- 1.5 vs 4.5 +/- 1.4). However, the number of preovulatory follicles on proestrus did not differ (6.0 +/- 1.2 vs 5.5 +/- 0.6). Estradiol, testosterone and progesterone concentrations on proestrus in mature rats averaged 38.8 pg, 56.1 pg, and 1.0 ng/ml of ovary, respectively. In the older proestrous rat, only estradiol was altered, increasing to 124.3 pg/mg. In addition, many of the preovulatory follicles within the aged ovary were larger (greater than 600u in diameter) than those within the mature ovary. On the day of estrus virtually all preovulatory follicles ovulated in the mature rat, whereas large follicles, less than or equal to 600u in diameter, remained in the older ovar...Continue Reading


Sep 1, 1976·Journal of Reproduction and Fertility·R W StegerJ Meites
Mar 1, 1977·Journal of Reproduction and Fertility·J J PelusoE S Hafez
Jul 1, 1977·Endocrinology·C S CampbellM G Firlit
Jul 1, 1977·Journal of Gerontology·S W Chan, J H Leathem
Dec 1, 1977·Endocrinology·G A EvansM G Rosenfeld
Dec 1, 1977·The Journal of Endocrinology·J H Leathem, N M Appel
Jul 1, 1977·The Anatomical Record·S L Quattropani
Mar 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J H Leathem, B H Shapiro
Jan 1, 1975·Neuroendocrinology·H Huang, J Meites
Sep 15, 1974·Experientia·M OyaM Asano
Oct 1, 1968·American Journal of Obstetrics and Gynecology·G B Talbert
Apr 1, 1970·Biology of Reproduction·M E FreemanN W Fugo
Jul 1, 1959·The Journal of Endocrinology·A M MANDL, M SHELTON


Jan 1, 1982·Cell and Tissue Research·J J Peluso, C Downey
May 15, 1990·Mechanisms of Ageing and Development·F FerranteF Amenta
Feb 1, 1992·Mechanisms of Ageing and Development·H ZhanJ H Zhou
Jan 1, 1982·Experimental Aging Research·R W Steger, J J Peluso
Feb 17, 2010·Reproductive Biology and Endocrinology : RB&E·Irina Y LebedevaNahid Parvizi
Aug 1, 1987·Environmental Health Perspectives·C A Montgomery, R H Alison
May 31, 2013·Reproductive Biology·Kazutoshi NishijimaShuji Kitajima
Sep 28, 2014·Brain Research·Stephanie L BakerCatherine Bielajew
Nov 2, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Gonzalo CruzAlfonso H Paredes
Jan 9, 2018·Journal of the Endocrine Society·Katrina M VolkNatalia Toporikova
Aug 28, 2020·Frontiers in Neurology·Andrew N StewartMelinda E Wilson
Jul 1, 1987·Veterinary Pathology·L S KellerC M Lang

Related Concepts

Estradiol, (16 alpha,17 beta)-Isomer
Atretic Follicle
Ovarian Cysts
Progesterone, (9 beta,10 alpha)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.