Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in rats.

Brain Research
Miriam GoebelYvette Taché

Abstract

Central activation of somatostatin (sst) receptors by oligosomatostatin analogs inhibits growth hormone and stress-related rise in catecholamine plasma levels while stimulating grooming, feeding behaviors, gastric transit and acid secretion, which can be mimicked by selective sst(2) receptor agonist. To evaluate the pattern of neuronal activation induced by peptide sst receptor agonists, we assessed Fos-expression in rat brain after intracerebroventricular (i.c.v.) injection of a newly developed selective sst(2) agonist compared to the oligosomatostatin ODT8-SST, a pan-sst(1-5) agonist. Ninety min after injection of vehicle (10 microl) or previously established maximal orexigenic dose of peptides (1 microg=1 nmol/rat), brains were assessed for Fos-immunohistochemistry and doublelabeling. Food and water were removed after injection. The sst(2) agonist and ODT8-SST induced a similar Fos distribution pattern except in the arcuate nucleus where only the sst(2) agonist increased Fos. Compared to ODT8-SST, the sst(2) agonist induced higher Fos-expression by 3.7-times in the basolateral amygdaloid nucleus, 1.2-times in the supraoptic nucleus (SON), 1.6-times in the magnocellular paraventricular hypothalamic nucleus (mPVN), 4.1-times i...Continue Reading

References

Oct 8, 1992·The Journal of Comparative Neurology·N S CanterasL W Swanson
Jan 1, 1991·Neurosurgical Review·M R Moore, P M Black
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Aug 22, 1985·The Journal of Comparative Neurology·R E Shapiro, R R Miselis
Oct 8, 1985·The Journal of Comparative Neurology·D F CechettoC B Saper
Feb 1, 1984·The Journal of Comparative Neurology·R B Hamilton, R Norgren
Jan 20, 1981·Neuroscience Letters·J E Nicholson, C M Severin
Mar 15, 1980·The Journal of Comparative Neurology·R J ContrerasR Norgren
Dec 1, 1994·The European Journal of Neuroscience·R M SeñarísP C Emson
Mar 1, 1995·Trends in Pharmacological Sciences·D HoyerJ E Taylor
May 15, 1993·The Journal of Comparative Neurology·P LerouxH Vaudry
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·K MesslingerR F Schmidt
Feb 7, 1998·Journal of Neurophysiology·M K Tallent, G R Siggins
Aug 6, 1999·Frontiers in Neuroendocrinology·Y C Patel

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Citations

Jun 1, 2015·Hormones and Behavior·Andreas StengelYvette Taché
May 17, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A StengelY Taché
May 14, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A StengelY Taché
May 11, 2011·Brain Research·Miriam Goebel-StengelYvette Taché
Dec 18, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miriam Goebel-StengelYvette Taché
Jul 18, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hiroshi KarasawaYvette Taché

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