PMID: 9182786Jun 27, 1997Paper

Pattern of malformations in the axial skeleton in human trisomy 13 fetuses

American Journal of Medical Genetics
I KjaerB Fischer Hansen

Abstract

The purpose of this study was to analyse the development of the axial skeleton in human trisomy 13 fetuses and to define which fields in the axial skeleton are affected in this condition. We investigated nine human fetuses with trisomy 13 and gestational ages of 14-19 weeks. Whole body radiographs and radiographs of midsagittal tissue blocks of the cranial base and the spine were studied. In the youngest fetus, 14 w GA, no malformations were observed. In eight fetuses, 17-19 weeks GA, malformations occurred in the lumbosacral spine. In four fetuses additional malformations were observed in the thoracic spine. The study showed that there was a correspondence between the extent of malformation in the lumbosacral spine and the thoracic spine. When mild malformation occurred in the lumbosacral region, no malformation was observed in the thoracic region, whereas malformation was observed in the thoracic region when there was extensive malformation in the lumbosacral region. Malformations did not occur in the cervical spine or the basilar part of the occipital bone, but the postsphenoidal part of the sphenoid bone was small and irregular in the six cases where it could be examined. In seven fetuses there was malformation or agenesis ...Continue Reading

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Citations

Dec 19, 2013·Gastroenterology Research and Practice·Tomasz GolabekPiotr Chlosta
Jun 18, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dorrit NoltingInger Kjaer
Jul 29, 2009·European Journal of Orthodontics·Inger Kjaer
Jun 30, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Larissa V FurtadoJohn M Opitz
Jan 24, 2009·American Journal of Medical Genetics. Part a·Liselotte SonnesenInger Kjaer
Apr 23, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F I VosC M Bilardo
May 29, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·I Kjaer
Jan 8, 1999·American Journal of Medical Genetics·I KjaerB Fischer Hansen
Aug 8, 1997·American Journal of Medical Genetics·I Kjaer, B Fischer Hansen
Oct 23, 1997·American Journal of Medical Genetics·I KjaerB F Hansen
Sep 1, 1999·American Journal of Medical Genetics·B R Korf
Dec 22, 2015·American Journal of Medical Genetics. Part a·Marco CastoriPaola Grammatico
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rochelle W TylJohn M Rogers
Jun 19, 1998·American Journal of Medical Genetics·C P Torfs, R E Christianson

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