Pattern of plasma testosterone and delta4-androstenedione in normal newborns: Evidence for testicular activity at birth.

The Journal of Clinical Endocrinology and Metabolism
M G Forest, A M Cathiard

Abstract

Plasma testosterone (T) and delta4-androstenedione (delta) levels were measured by a sensitive and specific radioimmunoassay method in 157 blood specimens from normal neonates. In both sexes at birth plasma T and delta were significantly higher in peripheral than in cord blood and drop within the first week of life. In males a secondary increase in both T and delta had occurred by the 2nd week of life while values continue to decrease in females. The present data demonstrate that testicular activity is still present at birth and suggest that the transient fall in T levels likely due to the removal of chorionic gonadotropin (hCG) secretion is responsible for the secondary activation of the hypothalamic pituitary axis by a negative feed-back mechanism.

Citations

Jul 1, 1992·Indian Journal of Pediatrics·N Josso
Jul 1, 1982·Indian Journal of Pediatrics·R K Danish
Jan 1, 1981·Progress in Lipid Research·J W SchmelingP W Ramwell
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·G PelletierF Labrie
Nov 1, 1978·Clinics in Endocrinology and Metabolism·S L Kaplan, M M Grumbach
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·J Müller, N E Skakkebaek
May 25, 2005·Developmental Psychology·Rebecca Christine KnickmeyerSimon Baron-Cohen
Mar 1, 1989·The Journal of Genetic Psychology·J A FineganP Y Wong
Sep 1, 1976·Clinical Endocrinology·M G ForestJ Bertrand
Nov 1, 1989·Journal of Endocrinological Investigation·R Penny, P Vecsei
Mar 9, 2010·European Journal of Endocrinology·Frédéric BrioudeJacques Young
Mar 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·P CorbierJ Roffi
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jenny Clarkson, Allan E Herbison
Aug 1, 1989·Clinical Endocrinology·N J BoltonR Vihko
Dec 1, 1980·The British Journal of Dermatology·P AgacheR Laurent
Nov 1, 1982·Clinics in Endocrinology and Metabolism·S G Ratcliffe
Nov 1, 1978·Clinics in Endocrinology and Metabolism·J S WinterW C Hobson
Nov 18, 2014·Frontiers in Endocrinology·Kai XiaRebecca C Knickmeyer
Oct 30, 1984·Biochemical and Biophysical Research Communications·O PascalJ André
May 1, 1980·Current Problems in Pediatrics·R L RosenfieldT D Allen
Sep 29, 2006·Journal of Child Neurology·Rebecca Christine Knickmeyer, Simon Baron-Cohen
Feb 1, 2020·Current Opinion in Obstetrics & Gynecology·Carole A Samango-SprouseAndrea L Gropman
Apr 23, 2020·Frontiers in Endocrinology·Carla Bizzarri, Marco Cappa
Oct 1, 1987·The Journal of Urology·M P LaQuagliaJ Mandell
May 2, 2019·Frontiers in Endocrinology·Silvina Beatriz MeroniSelva Beatriz Cigorraga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.