Pattern of primary resistance of Helicobacter pylori to metronidazole or clarithromycin in the United States

Archives of Internal Medicine
Michael S OsatoD Y Graham

Abstract

Therapy for Helicobacter pylori is generally empiric despite the fact that resistance to metronidazole and clarithromycin compromise therapeutic efficacy. The aim of this study was to aid clinicians in choosing a course of therapy for H pylori infection in the United States. The frequency of primary clarithromycin and metronidazole resistance among H pylori isolated from patients enrolled in US-based clinical trials between 1993 and 1999 was reviewed in relation to patient age, sex, region of the United States, and test method (Etest and 2 agar dilution procedures). Clarithromycin and metronidazole resistance rates were based on the results of 3439 pretreatment Etest determinations and 3193 agar dilution determinations. Sex and age were available on 900 and 823 individuals, respectively. Metronidazole resistance was 39% by Etest and 21.6% by agar dilution (P<.001). Clarithromycin resistance was 12% by Etest and 10.6% by agar dilution. Amoxicillin or tetracycline resistance was rare. Metronidazole and clarithromycin resistance was more common in women than men (eg, 34.7% vs 22.6% for metronidazole and 14.1% vs 9.7% for clarithromycin (P =.01 and P =.06, respectively). Antibiotic resistance increased gradually up to age 70 years,...Continue Reading

Citations

Oct 2, 2002·Lancet·Francis K L Chan, W K Leung
Sep 26, 2013·Journal of General Internal Medicine·Derrick Siao, Ma Somsouk
Jul 20, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mohammed RizwanAyesha Alvi
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Dong H KwonD Y Graham
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Osamu KamodaShigeru Kamiya
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
Oct 17, 2007·Gut·Francis Megraud
Dec 29, 2011·The Journal of Microbiology·Amin Talebi Bezmin AbadiD Scott Merrell
May 16, 2006·Digestive Diseases·Francesco Di MarioCarmelo Scarpignato
Apr 23, 2005·Digestive Diseases and Sciences·Seung Ha ParkDong Keuk Keum
Aug 2, 2002·Expert Opinion on Investigational Drugs·Paolo RuggieroGiuseppe Del Giudice
Jan 31, 2003·Expert Opinion on Investigational Drugs·David M RothsteinBarry I Eisenstein
Mar 1, 2016·Digestive Diseases and Sciences·Jason Y ParkChristopher D Doern
Nov 19, 2010·International Journal of Antimicrobial Agents·Pirkko KostamoHilpi Rautelin
Mar 7, 2015·Biological & Pharmaceutical Bulletin·Jibran Sualeh MuhammadToshiro Sugiyama
Jul 21, 2016·Journal of Global Antimicrobial Resistance·Valentina GehlotRajashree Das
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·K Wolle, P Malfertheiner
Jul 26, 2012·Gastroenterology Research and Practice·Wenming WuGang Sun
Dec 22, 2004·Microbiology and Immunology·Kyoko KanaiYoshichika Arakawa
Feb 5, 2005·Helicobacter·Kazuhiro WatanabeShin'ichi Takahashi
Aug 29, 2009·Helicobacter·Anthony O'ConnorColm O'Morain
Apr 29, 2004·Alimentary Pharmacology & Therapeutics·T T KoivistoM A Färkkilä

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