Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink

PloS One
Hilda J I De JongTjeerd P van Staa

Abstract

We examined the association between statin use and the risk of rheumatoid arthritis (RA), with special focus on describing the patterns of risks of RA during statin exposure in a large population-based cohort in the United Kingdom. In the Clinical Practice Research Datalink, patients aged ≥40 years with at least one prescription of statins (1995-2009) were selected, and matched by age (+/-5 years), sex, practice and date of first prescription of statins to non-users. The follow-up period of statin use was divided into periods of current, recent and past exposure, with patients moving between these three exposure categories over time. Time-dependent Cox models were used to derive hazard ratios (HRs) of RA, adjusted for disease history and previous drug use. The study population included 1,023,240 patients, of whom 511,620 were statin users. No associations were found between RA and current (HRadj,1.06;99%CI:0.88-1.27) or past statin users (HRadj,1.18;99%CI:0.88-1.57). However, in patients who currently used statins, hazard rates were increased shortly after the first prescription of statins and then gradually decreased to baseline level. The risk of developing RA was increased in recent statin users, as compared to non-users (HR...Continue Reading

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Citations

May 31, 2019·Current Opinion in Lipidology·Rachel H MackeyLarry W Moreland
Apr 16, 2020·Seminars in Arthritis and Rheumatism·Elena MyasoedovaCynthia S Crowson
Feb 2, 2019·Thérapie·Julien Bezin, Nicholas Moore
Oct 1, 2021·International Journal of Pharmaceutics·Parastou RahimizadehSung In Lim

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

SAS

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