Pattern of serum cytokine expression and T-cell subsets in sickle cell disease patients in vaso-occlusive crisis.

Clinical and Vaccine Immunology : CVI
Bolanle O P MusaAlbarka H Isa

Abstract

The pathogenesis of sickle vaso-occlusive crisis (VOC) in sickle cell disease (SCD) patients involves the accumulation of rigid sickle cells and the stimulation of an ongoing inflammatory response, as well as the stress of infections. The immune response, via cytokine imbalances and deregulated T-cell subsets, also has been proposed to contribute to the development of VOC. In this study, a panel of high-sensitivity cytokine kits was used to investigate cytokines in the sera of SCD patients in VOC. The results were compared primarily with those for stable SCD patients and secondarily with those for normal healthy people who served as controls. The cytokines studied included interleukin-2 (IL-2), IL-4, and IL-10. Lymphocyte subsets of patients with VOC were also studied and were compared with those of both control groups (20 stable patients without crisis [SCD group] and 20 normal healthy controls [NHC]). The VOC group was notable for remarkably elevated levels of IL-4, among the three cytokines tested, compared with those for the SCD and NHC groups. Patients with VOC also differed from stable SCD patients and NHC by having notably lower IL-10 levels, as well as the lowest ratio of CD4(+) to CD8(+) T cells (0.7). The patterns of ...Continue Reading

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Citations

Sep 16, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jennifer Knight-MaddenAnne Greenough
Sep 16, 2015·Journal of Medical Virology·Marina dos Santos Brito Silva FurtadoMarina Lobato Martins
Aug 1, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Amma Owusu-AnsahSolomon F Ofori-Acquah
Jul 5, 2012·European Journal of Haematology·Yasser WaliChristoph Klein
Jul 28, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lívia G CastilhosDaniela B R Leal
May 31, 2016·American Journal of Hematology·Emmanuel BalandyaJulie Makani
Jun 30, 2019·PloS One·Slimane AllaliMaria Leite-de-Moraes
Nov 25, 2019·Annals of Hematology·Suna SabuncuoğluGözde Girgin
Apr 5, 2018·Clinical Hemorheology and Microcirculation·Nicola Conran, John D Belcher
Nov 3, 2020·Mediators of Inflammation·Paula B DaltroVitor Fortuna
Feb 23, 2021·Frontiers in Immunology·Renata Sesti-CostaFernando Ferreira Costa
Mar 30, 2021·Frontiers in Immunology·Alexander Leonardo Silva-JuniorAdriana Malheiro
May 22, 2020·Immunology Letters·Júlia Teixeira Cottas de Azevedo, Kelen Cristina Ribeiro Malmegrim

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