PMID: 25777272Mar 18, 2015Paper

Pattern Recognition by CD6: a Scavenger-Like Lymphocyte Receptor

Current Drug Targets
Adelaida SarukhanFrancisco Lozano

Abstract

CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex. Because of this, its main function seems to involve the modulation of TCR-mediated signaling pathways. However, growing evidence indicates that this ancient and conserved scavenger-like receptor may also play a role as pattern recognition receptor (PRR), similar to other members of the scavenger receptor cysteine rich superfamily (SRCR-SF). Here we discuss the functional interactions of CD6 with microbe- and damage-associated signals and the potential use of soluble forms of CD6 in the therapeutic treatment of bacterial infections, in particular multi-drug resistant bacterial strains. Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored.

Citations

Dec 12, 2017·Cellular & Molecular Immunology·Marta Consuegra-FernándezFrancisco Lozano
Oct 12, 2019·Journal of Animal Science and Technology·Emmanuel Kwaku AsiamahMulumebet Worku
Nov 30, 2016·Antimicrobial Agents and Chemotherapy·Mario Martínez-FlorensaFrancisco Lozano
Mar 25, 2018·Cellular & Molecular Immunology·David A Fox

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