PMID: 591969Oct 1, 1977

Pattern reversal evoked visual potential in the diagnosis of multiple sclerosis

Journal of Neurology, Neurosurgery, and Psychiatry
W B MatthewsE Pountney

Abstract

The pattern reversal evoked visual potential (VEP) was recorded in 37 normal subjects and in 186 patients in whom a diagnosis of multiple sclerosis (MS) was established or suspected. Taking the upper limit of normal as the mean +2.5 SD (111 ms), prolonged latency was found in 75% of definite cases of MS, 58% of probable cases, and 38% of possible cases. A smaller number of patients without prolonged latency had abnormal asymmetry of latency or low amplitude potentials. In patients with a single acute episode of neurological disease resembling MS the incidence of abnormal VEP was very low. In patients examined within three months of an episode of retrobulbar neuritis (RBN), latency was prolonged in 81% of affected eyes, a similar proportion being found in patients with a more remote history of RBN. The importance of establishing the normal for every laboratory engaged on this investigation is emphasised. Prolonged latency of the VEP is common in established MS but has not yet been shown to be a sensitive diagnostic test of the early case.

References

Sep 25, 1976·British Medical Journal·F L MastagliaD W Collins
Jun 1, 1975·Brain : a Journal of Neurology·P AsselmanD C Marsden
May 6, 1972·Lancet·A M HallidayJ Mushin
Mar 31, 1973·Lancet·M Marshall
Dec 15, 1973·British Medical Journal·A M HallidayJ Mushin

Citations

Jun 16, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·N ToyonagaE Adachi
Nov 1, 1989·Documenta Ophthalmologica. Advances in Ophthalmology·B AshworthJ D Mitchell
Jan 1, 1980·Journal of Neurology·W Tackmann, E W Radü
Feb 1, 1980·Electroencephalography and Clinical Neurophysiology·L HappelC Garcia
Sep 1, 1980·Electroencephalography and Clinical Neurophysiology·H C Diener, H Scheibler
Jan 1, 1985·Electroencephalography and Clinical Neurophysiology·R CooperM Reed
Apr 1, 1986·Electroencephalography and Clinical Neurophysiology·R FukuiY Kuroiwa
Aug 1, 1986·Electroencephalography and Clinical Neurophysiology·S R Hammond, C Yiannikas
Feb 1, 1978·Journal of the Neurological Sciences·D G SmallM Small
Jan 1, 1979·Journal of the Neurological Sciences·W B Matthews, D G Small
Mar 1, 1980·Journal of the Neurological Sciences·K Robinson, P Rudge
Oct 1, 1986·Journal of the Neurological Sciences·M A HelyJ G McLeod
Jan 1, 1980·Clinical Neurology and Neurosurgery·S L Visser
Jun 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·B Y Nilsson
Apr 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·W Trojaborg, E Petersen
Mar 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·V H Patterson, J R Heron
Dec 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·H Shibasaki, Y Kuroiwa
Apr 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·W B MatthewsE Pountney
Jun 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·J C WalshJ G McLeod
Sep 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·J Bøttcher, W Trojaborg
Dec 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·G T Plant
Jul 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·W B Matthews, M Small
Mar 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·E A SandersL A Hogenhuis
Mar 15, 1979·Documenta Ophthalmologica. Advances in Ophthalmology·G H van LithG T van Dok-Mak
Nov 1, 1995·Electroencephalography and Clinical Neurophysiology·A BrusaS J Jones
Jan 1, 1988·Electroencephalography and Clinical Neurophysiology·M R NuwerL W Myers
Jan 1, 1982·Archiv für Psychiatrie und Nervenkrankheiten·H C DienerJ Dichgans
Jan 1, 1982·Annals of the New York Academy of Sciences·J Camisa, I Bodis-Wollner
Sep 1, 1980·Neuropathology and Applied Neurobiology·R C Tallis
Feb 1, 1984·Acta Neurologica Scandinavica·J M Gibson, P Kennedy
Jan 1, 1984·Annals of the New York Academy of Sciences·W T RothE Callaway
Aug 1, 2006·NeuroImage·Edmund C LalorJohn J Foxe
Oct 22, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Niphon ChirapapaisanNacha Chanvarapha
Sep 7, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Marius RingelsteinPhilipp Albrecht
Oct 1, 1992·Clinical EEG (electroencephalography)·R W FrithF Aitcheson
Dec 16, 1996·Annals of the New York Academy of Sciences·G W SmallA D Roses
Mar 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·W B MatthewsE Pountney
Oct 19, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Mathias Falck SchmidtJette Lautrup Frederiksen
Mar 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·G B YoungD Logan
Feb 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·P D ThompsonW M Carroll
Apr 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·M OnofrjL Mylin
Jan 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·S NightingaleP J Dawes
Apr 1, 1979·Clinical Genetics·H RothschildE Hackett
Dec 1, 1978·Acta Neurologica Scandinavica·K KayedB Kåss
May 1, 1982·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A Eisen
Jan 1, 1980·Scottish Medical Journal·B Ashworth
Apr 1, 1982·Scottish Medical Journal·J A Simpson
Jun 21, 2018·Current Neurology and Neuroscience Reports·Elizabeth SilbermannDennis Bourdette
Aug 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A EisenM Hoirch
Aug 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M JavidanK G Warren
Jan 19, 2021·Progress in Retinal and Eye Research·Amir H KashaniJohn M Ringman

Related Concepts

Teens
Electroencephalogram
Potentials, Event-Related
Form Perception
Ambidexterity
Multiple Sclerosis, Acute Fulminating
Optic Disk
Neuropapillitis
Pattern Recognition, Visual
Reaction Time

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.