Pattern, Stage, and Time of Recurrent Colorectal Cancer After Curative Surgery

Clinical Colorectal Cancer
Salman Yousuf Guraya

Abstract

Surgery remains the mainstay of curative treatment for colorectal cancer (CRC). Despite curative surgery, some patients experience cancer recurrence. However, the pattern, stage, and time of recurrent disease (RD) remain unknown. We aimed to determine the pattern and stage of RD after curative open and laparoscopic surgery for CRC. Databases were searched using selected keywords for clinical studies that analyzed the pattern, stage, and time of RD from CRC. A systematic protocol was used for data extraction, data synthesis, and interpretation of results. Of 455 publications retrieved from databases, 9 clinical studies were selected for this systematic review. There is substantial evidence that pulmonary recurrence is most commonly associated with rectal tumors, and multisite RD appears more frequently with right-sided CRC. RD from colon cancers predominantly appears early in liver, while recurrences from rectal cancer appear late in lungs. Approximately 30% to 50% of RD after curative resection of CRC occurs within the first 2 years; however, median time to recurrence is gradually increasing, particularly for patients with rectal cancers. Advanced primary CRC is significantly correlated with more locoregional and distant RD, wi...Continue Reading

Citations

May 13, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Xiaokang WangXiongzhi Wu
Feb 28, 2020·Experimental and Therapeutic Medicine·Zheng XiaoXi Zeng
Sep 11, 2020·Annals of Surgical Treatment and Research·Ulaş AdayHasan Akkoç
Apr 2, 2020·Molecular Diagnosis & Therapy·Hannah A Blair
Dec 23, 2020·Epigenomics·Mohammad Hossein PourhanifehAzam Hosseinzadeh
Sep 4, 2021·Clinical Radiology·P D HariaR Sinha

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