Oct 25, 2018

Patterned expression of Pannexin 1 channels in the adult cerebellar Purkinje cells

BioRxiv : the Preprint Server for Biology
Ady VisouCarole Levenes

Abstract

Pannexin1 (PanX1) are recently discovered proteins that can form large pore channels at the cell surface. They have been implicated in ATP dependent cell-to-cell communication and in several pathophysiological processes such as inflammation, cell death and epilepsy. Using immunohistochemistry in the adult mouse, we describe the presence of PanX1 in the deep cerebellar nuclei, in large cells of the granular layer, presumably Golgi interneurones, in some Bergmann glia radial processes as well as in the soma and dendrites of Purkinje cells. In the latter, PanX1, like many other proteins, distribute heterogeneously. Only Zebrin II positive Purkinje cells express PanX1, in accordance with the so-called zebra-striped modular architecture of the cerebellum. This distribution in zebra-stripes suggest that PanX1 may contribute to the control of ensemble activity within cerebellar microdomains or to the response of Purkinje cell to excitotoxicity and cell-death messages.

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Mentioned in this Paper

Immunohistochemistry
Golgi Apparatus
Cerebellar Nuclei
Epilepsy
Membrane Microdomains
Bergmann Astrocyte
Purkinje Cells
Stratum Granulosum
Neuroglia
Zebras

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