Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial

PloS One
Dongli SongBalaji Govindaswami

Abstract

To evaluate the effect of patterned, frequency-modulated oro-somatosensory stimulation on time to full oral feeds in preterm infants born 26-30 weeks gestation. This is a multicenter randomized controlled trial. The experimental group (n = 109) received patterned, frequency-modulated oral stimulation via the NTrainer system through a pulsatile pacifier and the control group (n = 101) received a non-pulsatile pacifier. Intent-to-treat analysis (n = 210) was performed to compare the experimental and control groups and the outcomes were analyzed using generalized estimating equations. Time-to-event analyses for time to reach full oral feeds and length of hospital stay were conducted using Cox proportional hazards models. The experimental group had reduction in time to full oral feeds compared to the control group (-4.1 days, HR 1.37 (1.03, 1.82) p = 0.03). In the 29-30 weeks subgroup, infants in the experimental group had a significant reduction in time to discharge (-10 days, HR 1.87 (1.23, 2.84) p < 0.01). This difference was not observed in the 26-28 weeks subgroup. There was no difference in growth, mortality or morbidities between the two groups. Patterned, frequency-modulated oro-somatosensory stimulation improves feeding de...Continue Reading

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Citations

Oct 16, 2020·Journal of Applied Physiology·Christopher J MayerlRebecca Z German
Oct 4, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jasmeet Kataria-HaleAmy Hair
Jan 30, 2021·Frontiers in Pediatrics·Sabrina ShandleyChristos Papadelis
Aug 28, 2021·Children·Joëlle ProvasiIsabelle Carchon

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Methods Mentioned

BETA
PMA

Clinical Trials Mentioned

NCT01158391

Software Mentioned

SAS
NTrainer

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