Patterns and Correlates of Participant Retention in a Multi-City Pre-Exposure Prophylaxis Demonstration Project

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Susanne Doblecki-LewisMichael A Kolber

Abstract

Safe and effective use of pre-exposure prophylaxis (PrEP) depends on retention in care after initial engagement. The United States PrEP Demonstration Project offered daily oral tenofovir/emtricitabine to participants in San Francisco, Miami, and Washington, D.C. for 48 weeks from 2012 to 2014. The Demo Project participants' patterns of retention were assigned to 1 of 3 categories: early loss to follow-up (ELTF) within the first 12 weeks of the study, retention throughout the study, or intermittent retention in which missed or delayed visits resulted in gaps in medication availability. For each group, baseline characteristics were tabulated. A two-step multivariable analysis was performed. Overall, 366/554 (66.1%) of enrolled participants were retained for all study visits, 127/554 (22.9%) had intermittent retention, and 61/554 (11.0%) ELTF. In multivariable analysis, Miami compared with San Francisco site was associated with ELTF rather than full retention [aOR 2.84; confidence interval (CI): 1.24 to 6.47] and also with intermittent rather than full retention (aOR 2.70; CI: 1.43 to 5.11). Younger age was associated with ELTF (aOR 1.80 for each 10-year decrement in age; CI: 1.26 to 2.57) and intermittent retention (aOR 1.47; CI:...Continue Reading

References

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Citations

Feb 16, 2019·Journal of the International AIDS Society·Douglas KrakowerKenneth H Mayer
Mar 14, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew A SpinelliAlbert Y Liu
Aug 31, 2019·AIDS and Behavior·Charlotte-Paige RolleDavid P Holland
Jun 14, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kelly A JohnsonStephanie E Cohen
Sep 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David P SerotaColleen F Kelley
Dec 3, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Jonathan KeyesCharlotte-Paige Rolle
Jun 9, 2021·AIDS·Fengyi JinUNKNOWN Expanded PrEP Implementation in Communities New South Wales (EPIC-NSW) research group
Dec 5, 2021·AIDS Research and Human Retroviruses·Andrew GoodmanKatherine Frasca
Dec 18, 2021·BMJ Global Health·Daniel J IkedaAlexander C Tsai

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