Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes

Breast Cancer Research and Treatment
Marcel SmidJohn W M Martens

Abstract

One of the hallmarks of human solid tumors is chromosomal instability (CIN). We studied global patterns as well as individual levels of CIN and determined the prognostic relevance among breast cancer subtypes. For this, we used single nucleotide polymorphism copy number data of 313 primary lymph-node negative breast cancers. The level of CIN for individual samples was determined by counting the total number of chromosomal segments showing a gain or loss per specimen. Hierarchical clustering resulted in four groups showing distinct patterns of abnormalities, predominantly characterized by 1q gain, 8q gain, 1q&8q gain, or no gain of these loci. Estrogen receptor (ER)-positive and ER-negative samples showed an uneven distribution (statistically significant) across the cluster-groups, as did the molecular subtypes and triple-negative tumors (negative for estrogen-, progesterone-, and her2/neu-receptor). The CIN-score was significantly higher in ER-negative and triple-negative samples. Among luminal cancers, luminal B had a higher CIN-score than luminal A. The CIN-score was significantly associated with prognosis, measured by the time to distant metastasis, in ER-positive, luminal B, and her2/neu subtypes, but not in ER-negative pat...Continue Reading

References

Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KallioniemiF M Waldman
Jan 1, 1999·Nature·C LengauerB Vogelstein
Sep 2, 1999·Nature Genetics·J R PollackP O Brown
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 30, 2000·Nature·C M PerouD Botstein
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Aug 7, 2002·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Michael D RadmacherRichard Simon
Dec 25, 2003·Bioinformatics·Jelle J GoemanHans C van Houwelingen
Dec 3, 2004·Cancer Research·Khawla Al-KurayaGuido Sauter
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 16, 2006·Journal of the National Cancer Institute·Christos SotiriouMauro Delorenzi
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John A FoekensYixin Wang
Jan 19, 2007·The New England Journal of Medicine·Rui LiuMichael F Clarke
Mar 14, 2007·Breast Cancer Research and Treatment·Rachel E EllsworthCraig D Shriver
May 3, 2008·Cancer Research·Marcel SmidJohn W M Martens
Jul 3, 2008·Cancer Research·Marcus SchmidtMathias Gehrmann
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabrice AndreLajos Pusztai
Dec 25, 2009·Nature·Philip J StephensMichael R Stratton

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Citations

Sep 4, 2010·Breast Cancer Research and Treatment·Alejandro Gru, D Craig Allred
May 24, 2011·Breast Cancer Research and Treatment·Musaffe TunaJohn A Foekens
Jan 16, 2013·Oncogene·P H G Duijf, R Benezra
Dec 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Samuel F BakhoumDuane A Compton
Apr 3, 2012·The Journal of Clinical Investigation·Samuel F Bakhoum, Duane A Compton
Sep 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry H YoonFrank A Sinicrope
Jul 12, 2014·BMC Genomics·Ewa PrzybytkowskiMark Basik
Oct 1, 2014·Breast Cancer Research and Treatment·Muhammad RiazJohn W M Martens
Sep 9, 2011·Breast Cancer Research and Treatment·Barbara BernasconiMaria Grazia Tibiletti
Sep 17, 2011·Cellular and Molecular Life Sciences : CMLS·Marieke A VolleberghSabine C Linn
Aug 10, 2015·The Breast : Official Journal of the European Society of Mastology·Daniel G Stover, Eric P Winer
May 19, 2012·EMBO Reports·Nicholas McGranahanCharles Swanton
Sep 18, 2012·The Journal of Steroid Biochemistry and Molecular Biology·K M McNamaraH Sasano
Nov 11, 2015·BMC Cancer·Maarten P G MassinkHanne Meijers-Heijboer
Oct 25, 2016·Biochimica Et Biophysica Acta·Otília MenyhártBalázs Győrffy
Dec 29, 2017·Cancers·Natalia Vargas-RondónMilena Rondón-Lagos
May 15, 2018·The Journal of Clinical Investigation·Rebecca L VartuliHeide L Ford
Feb 27, 2016·Biomarkers in Cancer·Bhavna S ParatalaKim M Hirshfield
May 4, 2018·Histopathology·Chitra JosephEmad A Rakha
May 31, 2012·British Journal of Cancer·A F MunroJ M S Bartlett
Dec 26, 2016·Journal of Pathology and Translational Medicine·Hyun Min KohYoung Hee Maeng
Nov 2, 2019·Genes·Enrique Hernández-LemusSoledad Ochoa
Jun 3, 2016·Cold Spring Harbor Perspectives in Medicine·Christine M Eischen
Apr 26, 2017·Pathology Oncology Research : POR·Yansong LiuLi Li
May 8, 2019·Breast Cancer Research : BCR·Olivia K Provance, Joan Lewis-Wambi
Dec 1, 2019·Scientific Reports·Kyoungyul LeeSo Yeon Park
May 21, 2015·American Society of Clinical Oncology Educational Book·Mary L Disis, Sasha E Stanton
Aug 5, 2016·Molecular Cancer Research : MCR·Jin-Ah KimXiao-Song Wang
Jan 15, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brionna Y HairKathleen Conway

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