Patterns and incidence of neural invasion in patients with cancers of the paranasal sinuses

Archives of Otolaryngology--head & Neck Surgery
Ziv GilDennis H Kraus

Abstract

To characterize the incidence and pattern of neural invasion (NI) in patients with cancers of the paranasal sinuses and anterior skull base. Retrospective study. A tertiary referral cancer center. The study included 208 patients with cancer of the paranasal sinuses. Patients with brain invasion or neurogenic tumors were excluded. Analysis of clinical and pathologic data on patients with cancer of the paranasal sinuses. Forty-one specimens (20%) had evidence of NI. Sinonasal undifferentiated, adenoid cystic, and squamous cell carcinoma had a high propensity for NI, whereas melanoma and sarcoma rarely invaded nerves. Intraneural invasion was found in 32% of these cases, and 34% invaded more than 1 cm distal to the tumor. Neural invasion was associated with a high rate of positive margins, maxillary origin, and previous surgical treatment (P < .04) but not with stage, orbital invasion, or dural invasion. Patients with NI were more likely to undergo adjuvant radiotherapy (P = .003), which significantly improved survival in patients with minor salivary gland carcinomas (P = .04). Multivariate analysis showed that pathologic evidence of NI was not an independent predictor of outcome. Paranasal carcinomas have high propensity for NI, ...Continue Reading

Citations

Aug 5, 2014·International Journal of Oral and Maxillofacial Surgery·M F AndradeA M Loyola
Jul 9, 2014·Radiología·B Brea Álvarez, M Tuñón Gómez
Oct 2, 2009·Oral and Maxillofacial Surgery·Bijan KhademiMohammad Mohammadianpanah
Feb 20, 2010·Journal of Cancer Research and Clinical Oncology·Lars-Christian HornBettina Hentschel
Nov 2, 2015·Critical Reviews in Oncology/hematology·Paolo BossiEster Orlandi
May 14, 2011·Advanced Drug Delivery Reviews·Peter BraderZiv Gil
May 14, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Wei-Ren ShenChun-Pin Chiang
Apr 6, 2013·Head & Neck·Vincent Vander PoortenAlfio Ferlito
Sep 21, 2010·Current Problems in Cancer·Miriam N LangoJohn A Ridge
May 17, 2015·Surgical Oncology Clinics of North America·Victoria BanuchiDennis Kraus
May 28, 2016·Insights Into Imaging·Sonam TashiPravin Mundada
Jan 21, 2017·Otolaryngologic Clinics of North America·Kyle WangBhishamjit S Chera
Apr 9, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Francisco J Barrera-FloresRodrigo E Elizondo-Omaña
Nov 23, 2010·International Journal of Surgical Pathology·Alexandra MeinelLars-Christian Horn
Jul 23, 2019·International Forum of Allergy & Rhinology·Eric W WangCarl H Snyderman
Aug 23, 2019·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jaroslav MichalekZdenek Dvorak
May 30, 2019·Clinical Oral Investigations·Alkananda SahooManas R Baisakh
Mar 28, 2020·OncoTargets and Therapy·Shorook Na'araZiv Gil
Mar 13, 2013·Expert Review of Anticancer Therapy·Navneet SinghEugene Yu
Jan 14, 2016·Laryngoscope Investigative Otolaryngology·Roman D LaskeGerhard F Huber
Jun 16, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·P S Harenberg, M Lehnhardt
Jul 27, 2021·Journal of Neurological Surgery. Part B, Skull Base·Anuraag S ParikhDerrick T Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Kaitlyn KellyZiv Gil
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Ziv GilRichard J Wong
American Journal of Clinical Oncology
William M MendenhallNancy P Mendenhall
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Martin DunnTrevor W Beer
© 2021 Meta ULC. All rights reserved