Patterns and predictors of conversion to bipolar disorder in 91 587 individuals diagnosed with unipolar depression

Acta Psychiatrica Scandinavica
Katherine L Musliner, Søren D Østergaard

Abstract

Conversion from unipolar depression (UD) to bipolar disorder (BD) is a clinically important event that should lead to treatment modifications. Unfortunately, recognition of this transition is often delayed. Therefore, the objective of this study was to identify predictors of diagnostic conversion from UD to BD. Historical prospective cohort study based on 91 587 individuals diagnosed with UD in Danish hospital psychiatry between 1995 and 2016. The association between a series of potential predictors and the conversion from UD to BD during follow-up (702 710 person-years) was estimated by means of Cox regression with death as competing risk. During follow-up, 3910 individuals with UD developed BD. The cumulative incidence of conversion was slightly higher in females (8.7%, 95% CI: 8.2-9.3) compared to males (7.7%, 95% CI: 7.0-8.4). The strongest predictor of conversion from UD to BD was parental history of BD (adjusted hazard ratio (aHR) = 2.60, 95% CI: 2.20-3.07)). Other predictors included psychotic depression at the index UD episode (aHR = 1.73, 95% CI: 1.48-2.02), a prior/concomitant non-affective psychosis (aHR = 1.73, 95% CI: 1.51-1.99), and in-patient treatment at the index episode (aHR = 1.76, 95% CI: 1.63-1.91). Diagnos...Continue Reading

References

Sep 20, 1996·American Journal of Medical Genetics·D BlackerE S Gershon
Oct 6, 2000·Biological Psychiatry·J Angst, R Sellaro
Aug 2, 2001·The American Journal of Psychiatry·J F GoldbergJ E Whiteside
Feb 8, 2007·The Journal of Clinical Psychiatry·Ekkehard OthmerSandra B Hall
Dec 14, 2007·Bipolar Disorders·Fernando S GoesJames B Potash
Feb 17, 2009·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Camilla BockLars Vedel Kessing
Dec 1, 1998·European Psychiatry : the Journal of the Association of European Psychiatrists·L Kessing
Nov 17, 2009·European Archives of Psychiatry and Clinical Neuroscience·A Carlo AltamuraEmanuela Mundo
May 13, 2010·Psychological Medicine·O J BienvenuK S Kendler
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Aug 4, 2011·Scandinavian Journal of Public Health·Ole MorsPreben Bo Mortensen
Aug 4, 2011·Scandinavian Journal of Public Health·Povl Munk-Jørgensen, Søren Dinesen Østergaard
Sep 29, 2011·Clinical Psychology & Psychotherapy·Jennifer L McDonald, Thomas D Meyer
Dec 12, 2012·Journal of Affective Disorders·Søren Dinesen OstergaardOle Mors
Mar 14, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
Oct 25, 2013·Acta Psychiatrica Scandinavica·R J BaldessariniC Visioli
Nov 13, 2013·Bipolar Disorders·Søren Dinesen ØstergaardJimmi Nielsen
May 9, 2014·JAMA Psychiatry·Carsten Bøcker PedersenWilliam W Eaton
Dec 3, 2014·Journal of Affective Disorders·Lars Vedel KessingPer Kragh Andersen
May 16, 2015·Journal of Affective Disorders·A Carlo AltamuraFrancesco Zanelli Quarantini
Sep 12, 2015·Acta Neuropsychiatrica·Louise BjørklundChristiane Gasse
Nov 20, 2016·Acta Psychiatrica Scandinavica·Katherine L MuslinerSøren D Østergaard
Jan 25, 2017·Molecular Psychiatry·J VaucherM V Holmes
Aug 5, 2017·Schizophrenia Research·Aswin RatheeshBarnaby Nelson

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Citations

Oct 31, 2018·Bipolar Disorders·Pedro Miguel Dos Santos OliveiraNuno Madeira
Aug 23, 2019·Acta Psychiatrica Scandinavica·Á López-DíazM Ruiz-Veguilla
Jun 7, 2019·Psychiatry and Clinical Neurosciences·Fernanda Pedrotti MoreiraRicardo A da Silva
Jul 11, 2020·Bipolar Disorders·Ole Köhler-ForsbergSøren D Østergaard
Sep 15, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melanie F PradierRoy H Perlis
Jul 15, 2020·The American Journal of Psychiatry·Katherine L MuslinerSøren D Østergaard
Jul 1, 2020·Frontiers in Psychiatry·Claire O'Donovan, Martin Alda
Nov 21, 2020·Acta Psychiatrica Scandinavica·Line Hofmann FrederiksenRikke Wesselhoeft
Apr 3, 2021·Journal of Affective Disorders·Romain IcickUNKNOWN BIPADD group of FACE, FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) Collaborators

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