Patterns and prognostic implications of low high-density lipoprotein levels in patients with non-ST-segment elevation acute coronary syndromes

European Heart Journal
Matthew T RoeEric D Peterson

Abstract

The patterns and prognostic significance of low high-density lipoprotein (HDL) cholesterol levels have not been well characterized. We sought to determine the prevalence and prognostic significance of low HDL cholesterol levels in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS). We evaluated HDL levels among NSTE ACS patients [ischaemic ECG (electrocardiogram) changes and/or positive cardiac markers] from the CRUSADE [Can Rapid Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC(American College of Cardiology)/AHA(American Heart Association) Guidelines] initiative treated at 555 US hospitals from January 2001 through June 2006. Clinical and angiographic characteristics, treatments, and in-hospital outcomes were analysed by categories of HDL levels measured during hospitalization. Among 93 263 NSTE ACS patients with HDL measurements, 16 854 (18.1%) had very low HDL levels (10-29 mg/dL), 32 185 (34.5%) had low HDL levels (30-39 mg/dL), 35 875 (38.5%) had normal HDL levels (40-59 mg/dL), and 8349 (9.0%) had high HDL levels (60-100 mg/dL). Patients with very low HDL levels were younger, more often male, and more commonly obese and diabetic. Patients wi...Continue Reading

References

Mar 10, 2004·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Sep 1, 2004·JAMA : the Journal of the American Medical Association·James A de LemosUNKNOWN Investigators
Sep 9, 2004·Radiation Protection Dosimetry·L Tommasino, S P Tripathy
Nov 28, 2006·The American Journal of Cardiology·Carine BoulonThierry Couffinhal
Mar 28, 2007·The New England Journal of Medicine·Steven E NissenUNKNOWN ILLUSTRATE Investigators
Mar 28, 2007·The New England Journal of Medicine·John J P KasteleinUNKNOWN RADIANCE 1 Investigators
Jun 15, 2007·The American Journal of Cardiology·Vincent E FriedewaldWilliam C Roberts
Jul 17, 2007·Lancet·Theodore Mazzone
Sep 28, 2007·The New England Journal of Medicine·Philip BarterUNKNOWN Treating to New Targets Investigators
Nov 7, 2007·The New England Journal of Medicine·Philip J BarterUNKNOWN ILLUMINATE Investigators
Nov 7, 2007·The New England Journal of Medicine·Daniel J Rader
Jan 5, 2008·Journal of the American College of Cardiology·Emil M deGomaPaul A Heidenreich
Jan 5, 2008·Journal of the American College of Cardiology·Carl J Lavie, Richard V Milani

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Citations

Sep 15, 2014·Clinical Biochemistry·Abdelghani BounafaaAbdelouahed Khalil
Mar 27, 2015·BioFactors·Fabiana H RachedAnatol Kontush
Oct 10, 2009·Journal of the American College of Cardiology·Robert P Giugliano, Eugene Braunwald
Oct 12, 2011·Journal of Cardiovascular Medicine·Gian Francesco MuredduLeonardo De Luca
Oct 4, 2012·Expert Review of Cardiovascular Therapy·Antonio M Gotto, Jennifer E Moon
Nov 26, 2009·Current Opinion in Lipidology

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