Patterns of altered functional connectivity in mesial temporal lobe epilepsy.

Epilepsia
Francesca PittauJean Gotman

Abstract

In mesial temporal lobe epilepsy (MTLE) the epileptogenic area is confined to the mesial temporal lobe, but other cortical and subcortical areas are also affected and cognitive and psychiatric impairments are usually documented. Functional connectivity methods are based on the correlation of the blood oxygen level dependent (BOLD) signal between brain regions, which exhibit consistent and reproducible functional networks from resting state data. The aim of this study is to compare functional connectivity of patients with MTLE during the interictal period with healthy subjects. We hypothesize that patients show reduced functional connectivity compared to controls, the interest being to determine which regions show this reduction. We selected electroencephalography-functional magnetic resonance imaging (EEG-fMRI) resting state data without EEG spikes from 16 patients with right and 7 patients with left MTLE. EEG-fMRI resting state data of 23 healthy subjects matched for age, sex, and manual preference were selected as controls. Four volumes of interest in the left and right amygdalae and hippocampi (LA, RA, LH, and RH) were manually segmented in the anatomic MRI of each subject. The averaged BOLD time course within each volume of...Continue Reading

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Citations

May 23, 2013·PloS One·Gong-Jun JiGuangming Lu
Jan 31, 2014·Radiology·Matthew N DeSalvoSteven M Stufflebeam
Apr 20, 2014·AJNR. American Journal of Neuroradiology·Q XuG Lu
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