Patterns of Ancestral Animal Codon Usage Bias Revealed through Holozoan Protists

Molecular Biology and Evolution
Jade SouthworthMartin Carr

Abstract

Choanoflagellates and filastereans are the closest known single celled relatives of Metazoa within Holozoa and provide insight into how animals evolved from their unicellular ancestors. Codon usage bias has been extensively studied in metazoans, with both natural selection and mutation pressure playing important roles in different species. The disparate nature of metazoan codon usage patterns prevents the reconstruction of ancestral traits. However, traits conserved across holozoan protists highlight characteristics in the unicellular ancestors of Metazoa. Presented here are the patterns of codon usage in the choanoflagellates Monosiga brevicollis and Salpingoeca rosetta, as well as the filasterean Capsaspora owczarzaki. Codon usage is shown to be remarkably conserved. Highly biased genes preferentially use GC-ending codons, however there is limited evidence this is driven by local mutation pressure. The analyses presented provide strong evidence that natural selection, for both translational accuracy and efficiency, dominates codon usage bias in holozoan protists. In particular, the signature of selection for translational accuracy can be detected even in the most weakly biased genes. Biased codon usage is shown to have coevol...Continue Reading

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Citations

Feb 20, 2020·Journal of the Royal Society, Interface·Yun DengTobias von der Haar
Mar 18, 2021·Scientific Reports·Danielle M MatrianoCecilia Conaco
Jun 15, 2021·Nucleic Acids Research·Adrian Gabriel TorresLluís Ribas de Pouplana

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Methods Mentioned

BETA
deamination

Software Mentioned

tRNAScan
CodonW
BLAST
SE
tRNA
Scan
SMALT

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