PMID: 9545464Jun 6, 1998

Patterns of base composition within the genes of Drosophila melanogaster

Journal of Molecular Evolution
Richard M Kliman, Adam Eyre-Walker

Abstract

Base composition is not uniform across the genome of Drosophila melanogaster. Earlier analyses have suggested that there is variation in composition in D. melanogaster on both a large scale and a much smaller, within-gene, scale. Here we present analyses on 117 genes which have reliable intron/exon boundaries and no known alternative splicing. We detect significant heterogeneity in G+C content among intron segments from the same gene, as well as a significant positive correlation between the intron and the third codon position G+C content within genes. Both of these observations appear to be due, in part, to an overall decline in intron and third codon position G+C content along Drosophila genes with introns. However, there is also evidence of an increase in third codon position G+C content at the start of genes; this is particularly evident in genes without introns. This is consistent with selection acting against preferred codons at the start of genes.

Citations

Nov 24, 2004·Journal of Molecular Evolution·Christoforos Nikolaou, Yannis Almirantis
Oct 10, 2006·Genetica·Frédérique Maczkowiak, Jean-Luc Da Lage
Nov 16, 2002·Current Opinion in Genetics & Development·L Duret
Jan 23, 1999·Current Opinion in Genetics & Development·H Akashi, Adam Eyre-Walker
Nov 11, 2006·Annual Review of Genetics·F Rodríguez-TrellesF J Ayala
Sep 15, 2005·Genetics·Nicolas GaltierNicolas Bierne
Nov 28, 2007·Genetics·Andreas Heger, Chris P Ponting
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Duret, D Mouchiroud
Jun 24, 2005·Molecular Biology and Evolution·Evgeniy S BalakirevF J Ayala

Related Concepts

G+C Composition
Drosophila melanogaster
Mini-Exon
Introns
Variation (Genetics)
Genes, Insect

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