PMID: 9417519Jan 1, 1997Paper

Patterns of Candida esophagitis in cancer and AIDS patients: histopathological study of 23 patients

Mycoses
M GörnigT J Walsh

Abstract

Candida oesophagitis is a common concomitant disease in neutropenic cancer patients after chemotherapie as well as in HIV-patients. In order to characterize the features of oesophagitis in each population, we reviewed the medical history and pathology records of 23 patients (18 cancer-patients, 5 HIV-patients) with culture and autopsy-proven Candida oesophagitis. Histopathological patterns of morphology, invasion, angioinvasion and inflammation were evaluated. Virtually all patients, 17/18 cancer- and 5/5 HIV-patients, had a history of previous mucosal candidosis or candidemia. There was a significant difference histopathologically in depth of invasion of the Candida-organisms between cancer and HIV-patients. Only in HIV-patients organisms were observed within the muscularis propria and the adventitia (2/5 vs 0/18; p = 0.04). The frequency of angioinvasion (12/18 vs 3/5) was similar in both groups. Neutropenia (< 500/microliter) was present in 12 (68%) of 18 cancer patients vs 0/5 HIV-patients (p = 0.01). Correspondingly there was a significant higher PMN/MN ratio in the oesophageal inflammatory infiltrate in HIV-patients, reflecting chemotherapy-induced neutropenia in cancer patients (p = 0.02). Oesophageal candidosis in HIV-p...Continue Reading

References

Sep 1, 1987·The Journal of Infectious Diseases·C PedersenJ Sindrup
Apr 1, 1986·American Journal of Clinical Pathology·T J Walsh, W G Merz
Feb 1, 1994·Gastroenterology·P H Baehr, G B McDonald

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Citations

Apr 14, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·Lucinda Calheiros GuimarãesSheila Jorge Adad

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