Patterns of care, associations and outcomes of chemotherapy for uterine serous carcinoma: analysis of the National Cancer Database

Gynecologic Oncology
Jose Alejandro Rauh-HainJohn O Schorge

Abstract

Evaluate rates of chemotherapy and radiotherapy delivery in the treatment of uterine serous carcinoma, and compare clinical outcomes of treated and untreated patients. The National Cancer Database was queried to identify patients diagnosed with uterine serous carcinoma between 2003 and 2011. The impact of chemotherapy on survival was analyzed using the Kaplan-Meier method. Factors predictive of outcome were compared using the Cox proportional hazards model. A total of 13,752 patients met the study eligibility criteria. Stage I, II, III, and IV disease accounted for 4355 (31.7%), 1023 (7.4%), 3484 (25.3%), and 2451 (17.8%) of the study population, respectively. 2439 (17.7%) women had unknown stage. Chemotherapy was administered in 4290 (35.4%) patients, radiotherapy to 1673 (12.2%), adjuvant chemo-radiation to 2915 (21.2%), and 4874 (35.4%) of women did not receive adjuvant therapy during the study period. Utilization of chemotherapy became more frequent over time. Over the entire study period, after adjusting for age, period of diagnosis, race, facility location, facility type, insurance provider, socioeconomic status, comorbidity index, lymph node dissection, treatment modality, and stage, there was an association between trea...Continue Reading

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Citations

Aug 20, 2016·Cancer Biomarkers : Section a of Disease Markers·Lin LuWei Meng
Apr 5, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Julian C HongJunzo P Chino
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Jan 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yanying LinJianliu Wang
Apr 9, 2020·Journal of Gynecologic Oncology·Jessie Y LiShari Damast

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