Abstract
Evaluate rates of chemotherapy and radiotherapy delivery in the treatment of uterine serous carcinoma, and compare clinical outcomes of treated and untreated patients. The National Cancer Database was queried to identify patients diagnosed with uterine serous carcinoma between 2003 and 2011. The impact of chemotherapy on survival was analyzed using the Kaplan-Meier method. Factors predictive of outcome were compared using the Cox proportional hazards model. A total of 13,752 patients met the study eligibility criteria. Stage I, II, III, and IV disease accounted for 4355 (31.7%), 1023 (7.4%), 3484 (25.3%), and 2451 (17.8%) of the study population, respectively. 2439 (17.7%) women had unknown stage. Chemotherapy was administered in 4290 (35.4%) patients, radiotherapy to 1673 (12.2%), adjuvant chemo-radiation to 2915 (21.2%), and 4874 (35.4%) of women did not receive adjuvant therapy during the study period. Utilization of chemotherapy became more frequent over time. Over the entire study period, after adjusting for age, period of diagnosis, race, facility location, facility type, insurance provider, socioeconomic status, comorbidity index, lymph node dissection, treatment modality, and stage, there was an association between trea...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Dec 14, 1999·Cancer·J R HoweC Scott-Conner
May 3, 2000·Lancet·C L CreutzbergM van Lent
Jan 9, 2001·Journal of Clinical Epidemiology·C N KlabundeJ L Warren
Jul 31, 2001·Best Practice & Research. Clinical Obstetrics & Gynaecology·C TropéV M Abeler
Jan 30, 2002·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael Thun
Dec 17, 2003·Gynecologic Oncology·Brian M SlomovitzKaren H Lu
Dec 17, 2003·Gynecologic Oncology·Warner K HuhRonald D Alvarez
Feb 27, 2004·Gynecologic Oncology·Henry M KeysUNKNOWN Gynecologic Oncology Group
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gini F FlemingR Tucker Burks
Dec 8, 2004·Gynecologic Oncology·William T CreasmanPeter Boyle
Sep 13, 2005·Gynecologic Oncology·C S DietrichJ R van Nagell
Oct 11, 2005·Gynecologic Oncology·Gregory SuttonRichard Zaino
Dec 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marcus E RandallUNKNOWN Gynecologic Oncology Group Study
Sep 27, 2006·Cancer·G Larry MaxwellUNKNOWN Gynecologic Oncology Group study
Mar 24, 2009·Cancer·Amanda Nickles FaderUNKNOWN Uterine Papillary Serous Carcinoma (UPSC) Consortium
May 26, 2009·Journal of Surgical Oncology·Mehul V RavalClifford Y Ko
Jul 14, 2009·Gynecologic Oncology·David M BorutaAlexander B Olawaiye
Mar 2, 2010·Lancet·Yukiharu TodoNoriaki Sakuragi
Mar 9, 2010·Lancet·R A NoutUNKNOWN PORTEC Study Group
Aug 10, 2010·Gynecologic Oncology·J Alejandro Rauh-HainMarcela G del Carmen
Jul 12, 2011·Gynecologic Oncology·Kate E OliverJohn H Farley
Jan 13, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Whitfield B GrowdonMarcela G del Carmen
Sep 25, 2012·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Feb 7, 2013·Gynecologic Oncology·Anuja JhingranThomas W Burke
Apr 24, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthew KoshyKatherine S Virgo
Oct 17, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michael Poullis
Oct 30, 2013·Annals of Surgical Oncology·Siavash RaiganiJohn B Ammori
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 18, 2014·Gynecologic Oncology·Jamie N Bakkum-GamezKarl C Podratz
Mar 14, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·J A Rauh-HainM G del Carmen
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Natasha M RuethGildy Babiera
Nov 8, 2014·Diseases of the Colon and Rectum·Asvin M GanapathiChristopher R Mantyh
Dec 5, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tina A AyeniSean C Dowdy
Dec 9, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFabio Ghezzi
Jan 13, 2015·Gynecologic Oncology·Haider MahdiRobert DeBenardo
Jan 13, 2015·International Journal of Surgery·Ioannis AlagkiozidisOvadia Abulafia
Mar 10, 2015·Obstetrics and Gynecology·J Alejandro Rauh-HainMarcela G Del Carmen
Apr 29, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jose Alejandro Rauh-HainMarcela G del Carmen
Oct 27, 2015·Rare Tumors·UNKNOWN Rare Cancer Network
Citations
Aug 20, 2016·Cancer Biomarkers : Section a of Disease Markers·Lin LuWei Meng
Apr 5, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Julian C HongJunzo P Chino
Mar 9, 2018·Gynecologic and Obstetric Investigation·Ahmed I GhanemMohamed A Elshaikh
Dec 23, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yanying LinJianliu Wang
Sep 26, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Shifeng TianQiang Wei
Mar 5, 2017·Annals of Surgical Oncology·Maria B SchiavoneNadeem R Abu-Rustum
Jan 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yanying LinJianliu Wang
Apr 9, 2020·Journal of Gynecologic Oncology·Jessie Y LiShari Damast