Patterns of chemical diversity in the marine ascidian Phallusia spp.: anti-tumor activity and metabolic pathway inhibiting steroid biosynthesis

3 Biotech
Satheesh Kumar PalanisamyUmamaheswari Sundaresan

Abstract

The complex nature of marine biodiversity is partially responsible for the lack of studies in Indian ascidian species, which often target a small number of novel biomolecules. We performed untargeted metabolomics using gas chromatography-mass spectrometry (GC-MS) in two invasive ascidian species to investigate the inter-specific chemical diversity of Phallusia nigra and P. arabica in search of drug-like properties and metabolic pathways. The chemical profiling of individual ascidian species was obtained using GC-MS, and the metabolites were determined by searching in NIST library and literature data. The principal component analysis of GC-MS mass spectral variables showed a clear discrimination of these two ascidian species based on the chemical composition and taxonomy. The metabolites, lipids, macrolides, and steroids contributed strongly to the discrimination of these two species. Results of this study confirmed that GC-MS-based chemical profiling could be utilized as a tool for chemotaxonomic classification of ascidian species. The extract of P. nigra showed promising anti-tumor activity against HT29 colon cancer 35 µM and MCF7-breast cancer (34.76 µM) cells compared to P. arabica. Of the more than 70 metabolites measured, ...Continue Reading

References

Feb 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C Thériault, F Labrie
Feb 17, 2005·Journal of Agricultural and Food Chemistry·Young Hae ChoiRobert Verpoorte
May 11, 2005·Chembiochem : a European Journal of Chemical Biology·Georg Pohnert
Feb 1, 2007·Journal of Chemical Ecology·Shobu Odate, Joseph R Pawlik
Mar 21, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Renata TakearaLetícia Veras Costa-Lotufo
Apr 3, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Paula C JimenezLetícia V Costa-Lotufo
Dec 20, 2008·Nature Reviews. Drug Discovery·Tadeusz F MolinskiJonel P Saludes
Jul 18, 2009·World Journal of Gastroenterology : WJG·Harris BernsteinKaterina Dvorak
Dec 28, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Denise FernandesCinta Porte
Jan 5, 2011·Steroids·Natalia V IvanchinaValentin A Stonik
Sep 14, 2011·BMC Complementary and Alternative Medicine·Ignacio PárragaJoseba Rabanales
Mar 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberta FerraldeschiGerhardt Attard
Nov 12, 2013·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Aug 30, 2014·The ISME Journal·Ma Diarey B TianeroEric W Schmidt
Jan 24, 2016·International Journal of Cardiology·M A MuñozJ M Verdú-Rotellar
Jan 18, 2017·Natural Products and Bioprospecting·Satheesh Kumar PalanisamyAngela Marino
Feb 25, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Satheesh Kumar PalanisamyAntonello Mai

❮ Previous
Next ❯

Citations

Apr 19, 2019·3 Biotech·Velusamy ArumugamSatheesh Kumar Palanisamy

❮ Previous
Next ❯

Related Concepts

© 2022 Meta ULC. All rights reserved